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Evolution of VX2 carcinoma in rabbit tibia: magnetic resonance imaging with pathologic correlation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, Jung-Ah | - |
dc.contributor.author | Kang, Eun Young | - |
dc.contributor.author | Kim, Han Kyeom | - |
dc.contributor.author | Song, In Chan | - |
dc.contributor.author | Kim, Young I I | - |
dc.contributor.author | Kang, Heung Sik | - |
dc.date.accessioned | 2010-06-27T23:42:12Z | - |
dc.date.available | 2010-06-27T23:42:12Z | - |
dc.date.issued | 2008-03-04 | - |
dc.identifier.citation | Clin Imaging. 2008;32(2):128-35 | en |
dc.identifier.issn | 0899-7071 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18313577 | - |
dc.identifier.uri | http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T5C-4S0MXC6-9-5&_cdi=4999&_user=168665&_orig=search&_coverDate=04%2F30%2F2008&_sk=999679997&view=c&wchp=dGLbVzW-zSkzV&md5=ed80d1510858b9aea413fa5c6793a917&ie=/sdarticle.pdf | - |
dc.identifier.uri | https://hdl.handle.net/10371/67846 | - |
dc.description.abstract | OBJECTIVE: To evaluate the evolution of a metastatic bone tumor model with MRI-pathology correlation. MATERIALS AND METHODS: VX2 carcinoma was implanted into the tibiae of 20 rabbits. The rabbits were divided into four groups of five (Groups I-IV). MRI was repeated at 1-week interval up to the fourth week, including sagittal T1-weighted image (T1WI), T2-weighted image (T2WI), gadolinium-enhanced fat-suppressed T1WI (GdT1WI), and diffusion-weighted image (DWI). Each group was sacrificed after the imaging, then histological examination for the tibiae with an implanted tumor was performed and MRI-pathologic correlation was done. RESULTS: On MRI-pathology correlation, the corresponding findings were as follows; low SI on T1WI, T2WI-tumor cells, fibrosis (1 week); central low SI on T1WI, T2WI, GdT1WI -tumor cells with fibrosis and necrosis; peripheral high SI on T2WI, DWI, GdT1WI-edema, fibrosis (2 weeks); heterogeneous SI with central low SI on T2WI, DWI-tumor cell nests with extensive necrosis, fibrosis; high SI on T2WI along periosteum-periosteal reaction; high SI around low SI and in bone marrow on T2WI, DWI, GdT1WI-edema, fibrosis; low SI on T1WI in surrounding bone marrow-tumor extension (3-4 weeks). CONCLUSION: The evolution of VX2 carcinoma model was well depicted on MR imaging. Necrosis and extent of tumor were best depicted on enhanced, fat-suppressed T1-weighted images. Heterogeneity of the tumor, peripheral edema, and fibrosis were represented well on T2-weighted images. Diffusion-weighted imaging could have a role in depicting necrosis in the evaluation of bone tumor. | en |
dc.language.iso | en | - |
dc.publisher | Elsevier | en |
dc.subject | Animals | en |
dc.subject | Bone Neoplasms/*pathology/*secondary | en |
dc.subject | Necrosis | en |
dc.subject | Neoplasm Transplantation | en |
dc.subject | Neoplasms, Experimental/pathology | en |
dc.subject | Rabbits | en |
dc.subject | Tibia/*pathology | en |
dc.subject | Magnetic Resonance Imaging | - |
dc.title | Evolution of VX2 carcinoma in rabbit tibia: magnetic resonance imaging with pathologic correlation | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 최정아 | - |
dc.contributor.AlternativeAuthor | 강은영 | - |
dc.contributor.AlternativeAuthor | 김한겸 | - |
dc.contributor.AlternativeAuthor | 송인찬 | - |
dc.contributor.AlternativeAuthor | 김영일 | - |
dc.contributor.AlternativeAuthor | 강흥식 | - |
dc.identifier.doi | 10.1016/j.clinimag.2007.08.021 | - |
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