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The prevalence of hepatitis B virus preS deletions occurring naturally in Korean patients infected chronically with genotype C

Cited 58 time in Web of Science Cited 59 time in Scopus
Authors
Mun, Ho-Suk; Lee, Seoung-Ae; Jee, Youngmee; Kim, Hong; Park, Joo-Hee; Song, Byung-Cheol; Yoon, Jung-Hwan; Kim, Yoon Jun; Lee, Hyo-Suk; Hyun, Jin-won; Hwang, Eung-Soo; Kook, Yoon-Hoh; Kim, Bum-Joon
Issue Date
2008-05-08
Publisher
Wiley-Blackwell
Citation
J Med Virol. 80(7):1189-1194
Keywords
AdultAmino Acid SequenceFemaleGenotypeHepatitis B Surface Antigens/chemistry/*geneticsHepatitis B virus/classification/*genetics/isolation & purificationHepatitis B, Chronic/epidemiology/*virologyHumansMaleMiddle AgedMolecular Sequence DataProtein Precursors/chemistry/*genetics*Sequence Deletion
Abstract
Although Korea is one of the endemic areas for hepatitis B virus infection (HBV), the prevalence of deletions in HBV preS region occurring naturally have not been determined. In the present study, the prevalence of preS deletions was determined in terms of clinical state and HBeAg serostatus in 120 patients with different clinical features [59 HBeAg positive, 61 HBeAg negative; 38 asymptomatic carriers, 21 patients with chronic hepatitis, 21 patients with liver cirrhosis, 40 patients with hepatocellular carcinoma (HCC)]. A total of 37 strains (30.8%) harbored deletions in the preS region. Overall, the frequencies of preS deletions tended to increase gradually according to the degree of the clinical severity of liver disease. The prevalence of preS1 deletions in HCC patients tended to be higher than in patients with liver cirrhosis (32.5% vs. 19%). The prevalence of preS2 deletions in HBeAg negative patients was significantly higher than in HBeAg positive patients (23% vs. 6.8%). The type of deletion encountered most frequently was one disrupting the preS1 start codon [14/37 strains (37.8%)], which showed a very high prevalence in HCC patients (9/40, 22.5%; HCC vs. asymptomatic carriers, P=0.048). These results suggest that there might be the discrepancy between preS1 and preS2 mutations in the mechanism of enhancing the progression of chronic liver disease, especially the development of HCC and to maintain tolerance during the stage of immune tolerance. Specific deletion of the type disrupting preS1 start codon may play important roles in hepatocarcinogenesis, at least in Korean patients with chronic HBV infection.
ISSN
0146-6615 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18461612

http://hdl.handle.net/10371/67862
DOI
https://doi.org/10.1002/jmv.21208
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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