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Effects of spatial resolution and tube current on computer-aided detection of polyps on CT colonographic images: phantom study

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dc.contributor.authorKim, Se Hyung-
dc.contributor.authorLee, Jeong Min-
dc.contributor.authorShin, Cheong-Il-
dc.contributor.authorKim, Hyo Chul-
dc.contributor.authorLee, Joon-Goo-
dc.contributor.authorKim, Jong Hyo-
dc.contributor.authorChoi, Jin Young-
dc.contributor.authorEun, Hyo Won-
dc.contributor.authorHan, Joon Koo-
dc.contributor.authorLee, Jae Young-
dc.contributor.authorChoi, Byung Ihn-
dc.date.accessioned2010-06-28-
dc.date.available2010-06-28-
dc.date.issued2008-02-10-
dc.identifier.citationRadiology. 2008;248(2):492-503en
dc.identifier.issn1527-1315 (Electronic)-
dc.identifier.issn0033-8419 (Print)-
dc.identifier.urihttp://hdl.handle.net/10371/67877-
dc.description.abstractPURPOSE: To prospectively evaluate the effects of z-axis spatial resolution and tube current on the sensitivity of a commercially available computed tomographic (CT) colonography computer-aided diagnosis (CAD) system for polyp detection by using pig colon phantoms. MATERIALS AND METHODS: Ninety-six polyps were created and analyzed in 14 pig colon phantoms. CT colonography was performed by using a 16-detector CT scanner at 0.75-mm collimation; 10, 50, 100, and 160 mAs; and a pitch of 1.5. At each milliampere-second setting, the CT images were reconstructed with a section thickness (ST) of 1.5 mm and a reconstruction increment (RI) of 1.3 mm. To evaluate the effect of z-axis spatial resolution, CT images were also reconstructed at 100 mAs with various SI and RI combinations (respectively: 1.0 and 0.7 mm, 3.0 and 2.0 mm, 3.0 and 3.0 mm, 5.0 and 5.0 mm). The phantom data were then analyzed by using a CAD program. CAD performance with different CT parameters was calculated and compared in terms of per-polyp sensitivity and number of false-positive (FP) findings per data set. RESULTS: At a constant tube current of 100 mAs, the polyp detection rate was significantly higher in data sets obtained with SI and RI combinations of 1.0 and 0.7 mm, respectively (81% [78/96]), and 1.5 and 1.3 mm, respectively (75% [72/96]), than in those obtained with the three thicker ST-RI settings (27% [26/96] to 64% [61/96]) (P < .01). A similar trend was observed, regardless of polyp size or morphology. However, the number of FP findings at the 1.0 mm and 0.7 mm setting (8.9 per phantom) was also significantly greater than that at the thicker ST-RI settings (4.0-6.1 per phantom) (P < .05). At a constant z-axis spatial resolution (1.5-mm ST, 1.3-mm RI), CAD polyp detection rate and number of FP findings per phantom remained nearly constant-close to 78% (75/96) and 6.1, respectively-at various tube current settings. CONCLUSION: CAD performance in polyp detection at CT colonography is highly dependent on z-axis spatial resolution. However, tube current is not an influencing factor in CAD performance at a given z-axis spatial resolution. Supplemental material: http://radiology.rsnajnls.org/cgi/content/full/2482071025/DC1.en
dc.language.isoenen
dc.publisherRadiological Society of North America (RSNA)en
dc.subjectAlgorithmsen
dc.subjectAnimalsen
dc.subjectColonic Polyps/*radiographyen
dc.subject*Colonography, Computed Tomographicen
dc.subjectFalse Positive Reactionsen
dc.subject*Phantoms, Imagingen
dc.subjectProspective Studiesen
dc.subject*Radiographic Image Interpretation, Computer-Assisteden
dc.subjectSensitivity and Specificityen
dc.subjectSwineen
dc.titleEffects of spatial resolution and tube current on computer-aided detection of polyps on CT colonographic images: phantom studyen
dc.typeArticleen
dc.contributor.AlternativeAuthor김세형-
dc.contributor.AlternativeAuthor이정민-
dc.contributor.AlternativeAuthor신정일-
dc.contributor.AlternativeAuthor김효철-
dc.contributor.AlternativeAuthor이준구-
dc.contributor.AlternativeAuthor김종효-
dc.contributor.AlternativeAuthor최진영-
dc.contributor.AlternativeAuthor은효원-
dc.contributor.AlternativeAuthor한준구-
dc.contributor.AlternativeAuthor이재영-
dc.contributor.AlternativeAuthor최병인-
dc.identifier.doi10.1148/radiol.2482071025-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Radiology (영상의학전공)Journal Papers (저널논문_영상의학전공)
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