S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Medicine (의학과) The Seoul Journal of Medicine The Seoul Journal of Medicine Vol. 36 No.1 (1995)
Reduced Expression of nm23 Protein is Related to Nodal Metastasis of Human Gastric Carcinoma
- Song, Sang -Yong; Chi, Je G.
- Issue Date
- Seoul J Med, Vol.36 No.1, pp. 9-14
- Reduced expression of nm23 gene or protein has been known to be
related with nodal metastasis in a variety of malignant tumors of the breast. lung.
liver, prostate. ovary and stomach. To elucidate a possible prognostic factor. we
studied 42 cases of gastric adenocarcinomas for the expression of nm23 protein
using immunohistochemical methods and compared with the known prognostic
parameters. The nm23 protein was intensely stained in the cytoplasm and/or the
nucleus of carcinoma cells in 9 cases(21.4%). The nm23 protein expression of the
non-metastatic group(46.7%) was higher than that of the nodal metastasis group(7.
4%). Perigastric lymph node rnetastasesipttl.Otrl) were more frequently found in the
nrn23 protein neqative group(75.8%) than in the nm23 positive group(22.2%). There
was no significant correlation between nrn23 protein expression and other parameters
such as patient age. sex. WHO grade. Lauren classification. depth of
invasion. location of tumor and size. The results suggest that nm23 protein expression
plays a role in suppression of nodal metastasis in the gastric adenocarcinoma.