Browse

Th1 and Th2 cytokine levels in nasopharyngeal aspirates from children with human bocavirus bronchiolitis

Cited 19 time in Web of Science Cited 22 time in Scopus
Authors
Chung, Ju-Young; Han, Tae Hee; Kim, Jung-Sik; Kim, Sang Woo; Park, Chung-Gyu; Hwang, Eung-Soo
Issue Date
2008-07-25
Publisher
Elsevier
Citation
J Clin Virol. 2008t;43(2):223-5
Keywords
Acute DiseaseBocavirus/genetics/*immunology/isolation & purificationBronchiolitis, Viral/*immunology/virologyChild, PreschoolCytokines/*metabolismFemaleHospitalizationHumansInfantMaleNasopharynx/virologyParvoviridae Infections/*immunology/virologyTh1 Cells/*immunologyTh2 Cells/*immunology
Abstract
BACKGROUND: Human bocavirus (hBoV) is regarded as one of the possible etiologic agents in lower respiratory tract infection and bronchial asthma exacerbation in children despite frequent co-detection with other respiratory viruses. The immunologic response in children with hBoV infection is still not clear. OBJECTIVES: To investigate the profiles of T helper-1 (Th1)/T helper-2 (Th2) cytokines in children with hBoV-associated bronchiolitis. STUDY DESIGN: This study utilized of 59 nasopharyngeal aspirates from 59 infants aged 24 months or younger, including 29 from children with hBoV-related bronchiolitis and 30 with respiratory syncytial virus (RSV)-related bronchiolitis. Eighteen infants hospitalized for elective surgeries were included as controls. Nasopharyngeal aspirates were tested simultaneously for cytokines interleukin (IL)-2, IL-4, IL-5, IL-10, interferon (IFN)-gamma, and tumor necrosis factor (TNF)-alpha using the Cytometric Bead Array. RESULTS: Significantly higher concentrations of IFN-gamma (p=0.0001), IL-2 (0.006), and IL-4 (p=0.0002) were observed in hBoV positive specimens than in controls. The concentration of IL-10 (p=0.04) and TNF-alpha (p=0.006) in the RSV-positive group was significantly higher than in the hBoV-positive group, while there was no difference in other cytokines concentration between the two groups. CONCLUSIONS: These results showed that both of Th1 and Th2 cytokines were increased in children with hBoV-related bronchiolitis compared to normal controls, but Th2-polarized responses were not observed.
ISSN
1386-6532 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18650126

http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6VJV-4T1X2MR-1-1&_cdi=6104&_user=168665&_orig=search&_coverDate=10%2F31%2F2008&_sk=999569997&view=c&wchp=dGLbVtz-zSkzk&md5=c5d4b1912bb9344696982547bdab26ca&ie=/sdarticle.pdf

http://hdl.handle.net/10371/67884
DOI
https://doi.org/10.1016/j.jcv.2008.06.008
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Microbiology (미생물학전공)Journal Papers (저널논문_미생물학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse