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Inhibitory effects of triphlorethol-A on MMP-1 induced by oxidative stress in human keratinocytes via ERK and AP-1 inhibition
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kang, Kyoung Ah | - |
dc.contributor.author | Zhang, Rui | - |
dc.contributor.author | Piao, Mei Jing | - |
dc.contributor.author | Ko, Dong Ok | - |
dc.contributor.author | Wang, Zhi Hong | - |
dc.contributor.author | Lee, Kyung | - |
dc.contributor.author | Kim, Bum Joon | - |
dc.contributor.author | Shin, Taekyun | - |
dc.contributor.author | Park, Jae Woo | - |
dc.contributor.author | Lee, Nam Ho | - |
dc.contributor.author | Yoo, Byoung Sam | - |
dc.contributor.author | Hyun, Jin Won | - |
dc.date.accessioned | 2010-06-28T01:36:28Z | - |
dc.date.available | 2010-06-28T01:36:28Z | - |
dc.date.issued | 2008-06-24 | - |
dc.identifier.citation | J Toxicol Environ Health A. 71(15):992-999 | en |
dc.identifier.issn | 1528-7394 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18569608 | - |
dc.identifier.uri | http://pdfserve.informaworld.com/271715_758494928_794223963.pdf | - |
dc.identifier.uri | https://hdl.handle.net/10371/67886 | - |
dc.description.abstract | Oxidative stress is known to generate reactive oxygen species (ROS) in cells, which subsequently induce the synthesis of matrix metalloproteinases (MMP) and an aging phenomenon. The protective effects of triphlorethol-A, derived from Ecklonia cava, were investigated against hydrogen peroxide (H(2)O(2))-induced damage using human skin keratinocytes. Data showed that triphlorethol-A inhibited ROS formation, induced catalase expression, inhibited DNA damage, and increased cell viability in keratinocytes. Triphlorethol-A treatment significantly reduced MMP-1 expression and production, compared to H(2)O(2)-treated cells. In addition, triphlorethol-A abrogated the activation of extracellular signal regulated protein kinase (ERK), which originates upstream of MMP-1 expression, and was induced by H(2)O(2) treatment. Moreover, triphlorethol-A inhibited DNA binding activity of activator protein-1 (AP-1), a downstream transcription factor of ERK. Data indicate that the antioxidative properties of triphlorethol-A involve the inhibition of MMP-1 via ERK and AP-1 inhibition. | en |
dc.language.iso | en | en |
dc.publisher | Taylor & Francis | en |
dc.subject | Blotting, Western | en |
dc.subject | Catalase/metabolism | en |
dc.subject | Cell Survival/drug effects | en |
dc.subject | Cells, Cultured | en |
dc.subject | Comet Assay | en |
dc.subject | DNA/drug effects | en |
dc.subject | DNA Damage | en |
dc.subject | Enzyme Induction | en |
dc.subject | Extracellular Signal-Regulated MAP Kinases/*antagonists & inhibitors | en |
dc.subject | Fluorescent Antibody Technique, Indirect | en |
dc.subject | Free Radical Scavengers/*pharmacology | en |
dc.subject | Humans | en |
dc.subject | Hydrogen Peroxide/pharmacology | en |
dc.subject | Keratinocytes/*drug effects/enzymology | en |
dc.subject | Matrix Metalloproteinase 1 | en |
dc.subject | Oxidants/pharmacology | en |
dc.subject | Oxidative Stress | en |
dc.subject | Phloroglucinol/*analogs & derivatives/pharmacology | en |
dc.subject | Transcription Factor AP-1/*antagonists & inhibitors | en |
dc.title | Inhibitory effects of triphlorethol-A on MMP-1 induced by oxidative stress in human keratinocytes via ERK and AP-1 inhibition | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 강경아 | - |
dc.contributor.AlternativeAuthor | 고동옥 | - |
dc.contributor.AlternativeAuthor | 이경 | - |
dc.contributor.AlternativeAuthor | 김범준 | - |
dc.contributor.AlternativeAuthor | 신태균 | - |
dc.contributor.AlternativeAuthor | 박재우 | - |
dc.contributor.AlternativeAuthor | 이남호 | - |
dc.contributor.AlternativeAuthor | 유병삼 | - |
dc.contributor.AlternativeAuthor | 현진원 | - |
dc.identifier.doi | 10.1080/01932690801934653 | - |
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