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Protective effect of triphlorethol-A from Ecklonia cava against ionizing radiation in vitro

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dc.contributor.authorKang, Kyoung-Ah-
dc.contributor.authorZhang, Rui-
dc.contributor.authorLee, Kyoung Hwa-
dc.contributor.authorChae, Sungwook-
dc.contributor.authorKim, Bum Joon-
dc.contributor.authorKwak, Young Sook-
dc.contributor.authorPark, Jae Woo-
dc.contributor.authorLee, Nam Ho-
dc.contributor.authorHyun, Jin Won-
dc.date.accessioned2010-06-28T03:39:27Z-
dc.date.available2010-06-28T03:39:27Z-
dc.date.issued2006-03-31-
dc.identifier.citationJ Radiat Res (Tokyo). 47(1): 61-68en
dc.identifier.issn0449-3060 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16571919-
dc.identifier.urihttp://hdl.handle.net/10371/67901-
dc.description.abstractWe studied the cytoprotective effect of triphlorethol-A against gamma-ray radiation-induced oxidative stress. In this study, hydrogen peroxide, which is a reactive oxygen species (ROS), was detected using 2',7'-dichlorodihydrofluorescein diacetate (DCF-DA) assay. Triphlorethol-A reduced intracellular hydrogen peroxide generated by gamma-ray radiation. This compound provided protection against radiation-induced membrane lipid peroxidation and cellular DNA damage which are the main targets of radiation-induced damage. Triphlorethol-A protected the cell viability damaged by the radiation through inhibition of apoptosis. Triphlorethol-A reduced the expression of bax and activated caspase 3 induced by radiation, but recovered the expression of bcl-2 decreased by radiation. Taken together, the results suggest that triphlorethol-A protects cells against oxidative damage induced by radiation through reducing ROS.en
dc.language.isoenen
dc.publisherJapan Radiation Reseach Societyen
dc.subjectAlgae, Brown/*metabolismen
dc.subjectAnimalsen
dc.subjectCell Survival/*drug effects/*radiation effectsen
dc.subjectCricetinaeen
dc.subjectCricetulusen
dc.subjectDNA Damage/*radiation effectsen
dc.subjectDose-Response Relationship, Drugen
dc.subjectFibroblasts/cytology/drug effects/*physiology/radiation effectsen
dc.subjectGamma Raysen
dc.subjectLipid Peroxidation/drug effectsen
dc.subjectPhloroglucinol/administration & dosage/*analogs & derivativesen
dc.subjectRadiation-Protective Agents/administration & dosageen
dc.subjectReactive Oxygen Species/*metabolismen
dc.titleProtective effect of triphlorethol-A from Ecklonia cava against ionizing radiation in vitroen
dc.typeArticleen
dc.contributor.AlternativeAuthor강경아-
dc.contributor.AlternativeAuthor이경화-
dc.contributor.AlternativeAuthor채성욱-
dc.contributor.AlternativeAuthor김범준-
dc.contributor.AlternativeAuthor곽영숙-
dc.contributor.AlternativeAuthor박재우-
dc.contributor.AlternativeAuthor이남호-
dc.contributor.AlternativeAuthor현진원-
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College of Medicine/School of Medicine (의과대학/대학원)Microbiology (미생물학전공)Journal Papers (저널논문_미생물학전공)
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