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Relationships between the insulin-like growth factor I (IGF-I) receptor gene G3174A polymorphism, serum IGF-I levels, and bone mineral density in postmenopausal Korean women
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Dong Ock | - |
dc.contributor.author | Jee, Byung Chul | - |
dc.contributor.author | Ku, Seung-Yup | - |
dc.contributor.author | Suh, Chang Suk | - |
dc.contributor.author | Kim, Seok Hyun | - |
dc.contributor.author | Choi, Young Min | - |
dc.contributor.author | Moon, Shin Yong | - |
dc.contributor.author | Kim, Jung Gu | - |
dc.date.accessioned | 2010-06-30T07:54:18Z | - |
dc.date.available | 2010-06-30T07:54:18Z | - |
dc.date.issued | 2007-12-21 | - |
dc.identifier.citation | J Bone Miner Metab.26(1):42-46 | en |
dc.identifier.issn | 0914-8779 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18095062 | - |
dc.identifier.uri | http://www.springerlink.com/content/h24h7x5622064270/fulltext.pdf | - |
dc.identifier.uri | https://hdl.handle.net/10371/68071 | - |
dc.description.abstract | We investigated the relationships between the IGF-I receptor gene G3174A polymorphism, serum IGF-I levels, and bone mineral density (BMD) in postmenopausal Korean women. The IGF-I receptor gene G3174A polymorphism was analyzed in 367 postmenopausal Korean women. Serum levels of IGF-I, bone turnover markers (osteocalcin, bone alkaline phosphatase, carboxy-terminal cross-linking telopeptide of type I collagen), and BMD at the lumbar spine and proximal femur were measured. The frequencies of the AA, GA, and GG genotypes were 10.9%, 44.1%, and 45.0%, respectively. BMD at the lumbar spine was significantly higher for the AA genotype than the other genotypes and showed an A allelic dose effect; however, no significant differences in BMD were observed at the proximal femur with respect to genotype. No differences were noted between the three genotypes in terms of serum levels of IGF-I or bone turnover markers. Women with low BMD showed a lower prevalence of the AA genotype and A allele than age-matched women with normal BMD. Women with the AA genotype were found to have about half the risk of a low BMD than women with other genotypes. In conclusion, IGF-I receptor gene G3174A polymorphism is associated with lumbar spine BMD in postmenopausal Korean women. | en |
dc.description.sponsorship | This study was supported by the Seoul National
University Hospital Research Fund (grant no. 04-2004-037-0). | en |
dc.language.iso | en | en |
dc.publisher | Springer Verlag | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Female | en |
dc.subject | Humans | en |
dc.subject | Insulin-Like Growth Factor I/*metabolism | en |
dc.subject | Korea | en |
dc.subject | Middle Aged | en |
dc.subject | Receptor, IGF Type 1/*genetics | en |
dc.subject | Bone Density | - |
dc.subject | Polymorphism, Genetic | - |
dc.subject | Postmenopause | - |
dc.title | Relationships between the insulin-like growth factor I (IGF-I) receptor gene G3174A polymorphism, serum IGF-I levels, and bone mineral density in postmenopausal Korean women | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 이동옥 | - |
dc.contributor.AlternativeAuthor | 지병철 | - |
dc.contributor.AlternativeAuthor | 구승엽 | - |
dc.contributor.AlternativeAuthor | 서창석 | - |
dc.contributor.AlternativeAuthor | 김석현 | - |
dc.contributor.AlternativeAuthor | 최영민 | - |
dc.contributor.AlternativeAuthor | 문신용 | - |
dc.contributor.AlternativeAuthor | 김정구 | - |
dc.identifier.doi | 10.1007/s00774-007-0795-3 | - |
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