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Helicobacter pylori stool antigen (HpSA) tests in children before and after eradication therapy: comparison of rapid immunochromatographic assay and HpSA ELISA

Cited 25 time in Web of Science Cited 29 time in Scopus
Authors
Yang, Hye Ran; Seo, Jeong Kee
Issue Date
2007-12-05
Publisher
Springer Verlag
Citation
Dig Dis Sci. 53(8):2053-2058
Keywords
AdolescentAntigens, Bacterial/*analysisChildChild, PreschoolChromatography/*methods*Enzyme-Linked Immunosorbent AssayFeces/*microbiologyGastroscopyHelicobacter Infections/*diagnosis/drug therapy/microbiologyHelicobacter pylori/*immunologyHumansInfantPredictive Value of TestsReproducibility of ResultsSensitivity and SpecificityTreatment Outcome
Abstract
The rapid immunochromatography for Helicobacter pylori (H. pylori) stool antigen (rapid HpSA) test is a recently-developed method for detection of H. pylori infection. The objective of this study was to assess the pre and post-eradication diagnostic accuracy of the rapid HpSA test compared with the conventional HpSA immunoassay (HpSA ELISA) in children. Sensitivity, specificity, positive predictive value, and negative predictive value for the rapid HpSA test were 94.6, 98.4, 94.6, and 98.4%, respectively, and those for the HpSA ELISA were 94.6, 96.1, 87.5, and 98.4%, respectively. No significant difference was observed between the sensitivity and specificity of the two HpSA tests in children (P = 1.000 and P = 0.250) or the sensitivity and specificity of the two HpSA tests pre and post-eradication therapy (P = 1.000 and P = 1.000). The rapid HpSA and HpSA ELISA are reliable methods of detection of H. pylori infection in the pediatric population before and after eradication therapy.
ISSN
0163-2116 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18080196

http://www.springerlink.com/content/8248328754712147/fulltext.pdf

http://hdl.handle.net/10371/68148
DOI
https://doi.org/10.1007/s10620-007-0131-8
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Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Pediatrics (소아과학전공)Journal Papers (저널논문_소아과학전공)
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