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Renal expression of galectin-3 in systemic lupus erythematosus patients with nephritis

Cited 33 time in Web of Science Cited 31 time in Scopus
Authors
Kang, E H; Moon, K C; Lee, E Y; Lee, Y J; Lee, E B; Ahn, C; Song, Y W
Issue Date
2008-12-17
Publisher
SAGE Publications
Citation
Lupus. 2009; 18(1): 22-28
Keywords
AdultAntibodies, AntinuclearComplement C3/metabolismComplement C4/metabolismDNA/metabolismEnzyme-Linked Immunosorbent AssayFemaleGalectin 3/*genetics/metabolism*Gene ExpressionHumansImmunohistochemistryKidney Glomerulus/*metabolism/pathologyLupus Erythematosus, Systemic/*geneticsLupus Nephritis/*genetics/metabolismMaleYoung Adult
Abstract
The aim of the study is to characterize the expression pattern of galectin-3 (Gal-3) in renal tissues of patients with systemic lupus erythematosus (SLE) nephritis and to determine whether tissue and serum Gal-3 are associated with SLE nephritis. Gal-3 expressions were examined with immunohistochemistry in renal biopsy specimens of 88 patients with SLE nephritis and in five normal specimens. Activity and chronicity indexes and glomerular Gal-3 expressions were analysed in each specimen. Serum Gal-3 levels were measured using enzyme-linked immunosorbent assays in 20 patients with SLE, including 11 with nephritis, and in 50 healthy controls. Glomerular Gal-3 expression was observed in 81.8% (72/88) of patients with SLE nephritis but not in 5 controls. Gal-3 staining was attributed mainly to its cellular expression rather than its deposition, and Gal-3 expression levels were correlated with histologic activity indexes, anti-dsDNA titers, and complement 3 and 4 levels. Serum Gal-3 levels were higher in patients with SLE, particularly in those with nephritis, than in healthy controls, and correlated with anti-dsDNA titers. In conclusion, glomerular Gal-3 expression in renal tissue and serum Gal-3 levels were elevated in patients with SLE nephritis versus healthy controls; moreover, they reflected disease activity. These findings suggest that Gal-3 might contribute to the inflammatory process in SLE.
ISSN
0961-2033 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19074165

http://lup.sagepub.com/cgi/reprint/18/1/22.pdf

http://hdl.handle.net/10371/68210
DOI
https://doi.org/10.1177/0961203308094361
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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