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Effective second-line chemotherapy for extranodal NK/T-cell lymphoma consisting of etoposide, ifosfamide, methotrexate, and prednisolone

Cited 29 time in Web of Science Cited 33 time in Scopus
Authors
Kim, B-S; Kim, D-W; Im, S-A; Kim, C W; Kim, T-Y; Yoon, S-S; Heo, D S; Bang, Y-J; Park, S; Kim, B K; Kim, N K
Issue Date
2008-08-08
Publisher
Oxford University Press
Citation
Ann Oncol. 2009;20(1): 121-128
Keywords
AdultAgedAntineoplastic Combined Chemotherapy Protocols/adverseeffects/*therapeutic useChemotherapy, Adjuvant/adverse effectsDisease-Free SurvivalDrug Resistance, Neoplasm/drug effectsEtoposide/*administration & dosage/adverse effectsFemaleHumansIfosfamide/*administration & dosage/adverse effectsLymphoma, Extranodal NK-T-Cell/*drug therapy/mortality/pathologyMaleMethotrexate/*administration & dosage/adverse effectsMiddle AgedNeoadjuvant TherapyPrednisolone/*administration & dosage/adverse effectsRecurrenceSurvival AnalysisTreatment OutcomeYoung Adult
Abstract
BACKGROUND: Many patients with extranodal natural killer/T-cell lymphoma (NTCL) fail to the front-line therapy and need an effective second-line chemotherapy. PATIENTS AND METHODS: This was single-institutional, phase II study. The primary end point was response rate and secondary end points were toxicity, time to treatment failure (TTF), and overall survival (OS). Patients with relapsed or refractory NTCL were eligible. They received the chemotherapy consisting of ifosfamide, methotrexate, etoposide, and prednisolone and it was repeated every 3 weeks. RESULTS: Thirty-two patients were enrolled and 15 patients had achieved partial remission (PR) or complete remission (CR) after the front-line chemotherapy. The International Prognostic Index scores were 0-1 in thirteen, 2 in five, 3 in five, and 4-5 in nine patients. Twelve and two patients achieved CR and PR, respectively. Median OS and TTF of all patients were 8.2 and 3.7 months, respectively. Non-hematologic toxic effects were well tolerated, but grade 3/4 leukopenia occurred in 11.7% of all cycles. Four patients developed febrile neutropenia and one patient died due to pneumonia. CONCLUSIONS: This chemotherapy regimen was moderately effective for relapsed/refractory extranodal NTCL, nasal type. Toxic effects were moderate, but caution should be exercised to prevent severe infection.
ISSN
1569-8041 (Electronic)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18684695

http://annonc.oxfordjournals.org/cgi/reprint/20/1/121.pdf

http://hdl.handle.net/10371/68236
DOI
https://doi.org/10.1093/annonc/mdn551
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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