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Solid-organ malignancy as a risk factor for tuberculosis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Hye-Ryoun | - |
dc.contributor.author | Hwang, Seung Sik | - |
dc.contributor.author | Ro, Yun Kwan | - |
dc.contributor.author | Jeon, Chang Ho | - |
dc.contributor.author | Ha, Dong Yeob | - |
dc.contributor.author | Park, Sung Joon | - |
dc.contributor.author | Lee, Chang-Hoon | - |
dc.contributor.author | Lee, Sang-Min | - |
dc.contributor.author | Yoo, Chul-Gyu | - |
dc.contributor.author | Kim, Young Whan | - |
dc.contributor.author | Han, Sung Koo | - |
dc.contributor.author | Shim, Young-Soo | - |
dc.contributor.author | Yim, Jae-Joon | - |
dc.date.accessioned | 2010-07-05T03:47:00Z | - |
dc.date.available | 2010-07-05T03:47:00Z | - |
dc.date.issued | 2008-04-11 | - |
dc.identifier.citation | Respirology. 2008; 13(3): 413-419 | en |
dc.identifier.issn | 1440-1843 (Electronic) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18399865 | - |
dc.identifier.uri | https://hdl.handle.net/10371/68255 | - |
dc.description.abstract | BACKGROUND AND OBJECTIVE: The effective control of tuberculosis (TB) requires that people at high risk for the reactivation of TB are identified. Haematological malignancy has been shown to be a risk factor for the development of TB, either through immune suppression by the tumour or through the effects of chemotherapy. This study assessed the hypothesis that solid-organ malignancy is a risk factor for the development of TB. METHODS: A retrospective cohort study was performed to determine the incidence of TB in patients with solid-organ malignancy and in control subjects without malignancy. Risk factors for the development of TB among patients with cancer were also assessed. RESULTS: The study recruited 1809 cases with cancer and 1809 control subjects and followed them for 3 years. The incidence of active TB per 1000 person-years was 3.07 in patients with cancer and 0.77 in controls (P = 0.009). Compared with the control group, patients with cancer had an increased risk of developing TB (incidence rate ratio (IRR) 4.69, 95% CI: 1.52-14.46). Proportional hazards regression analysis showed that the risk factors for development of TB were chronic renal failure (IRR 9.91, 95% CI: 1.17-83.60), old healed TB on CXR (IRR 45.05, 95% CI: 5.74-353.88), and anticancer chemotherapy (IRR 4.32, 95% CI: 1.10-16.89). An interaction between old healed TB and anticancer chemotherapy was observed. CONCLUSION: These findings indicate that immune suppression by cancer or by anticancer chemotherapy increases vulnerability to reactivation of TB, especially in cancer patients with old healed TB. | en |
dc.description.sponsorship | This study was funded by grant 04-2006-098-0 from
the Seoul National University College of Medicine Research Fund (Seoul, Korea). | en |
dc.language.iso | en | en |
dc.publisher | Wiley-Blackwell | en |
dc.subject | Adolescent | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Aged, 80 and over | en |
dc.subject | Antineoplastic Agents/therapeutic use | en |
dc.subject | Breast Neoplasms/drug therapy/*epidemiology | en |
dc.subject | Case-Control Studies | en |
dc.subject | Cohort Studies | en |
dc.subject | Colonic Neoplasms/drug therapy/*epidemiology | en |
dc.subject | Drug Therapy | en |
dc.subject | Female | en |
dc.subject | Humans | en |
dc.subject | Immunosuppression | en |
dc.subject | Liver Neoplasms/drug therapy/*epidemiology | en |
dc.subject | Lung Neoplasms/drug therapy/*epidemiology | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Regression Analysis | en |
dc.subject | Retrospective Studies | en |
dc.subject | Risk Factors | en |
dc.subject | Stomach Neoplasms/drug therapy/*epidemiology | en |
dc.subject | Tuberculosis, Pulmonary/*epidemiology | en |
dc.title | Solid-organ malignancy as a risk factor for tuberculosis | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김혜련 | - |
dc.contributor.AlternativeAuthor | 황승식 | - |
dc.contributor.AlternativeAuthor | 노윤관 | - |
dc.contributor.AlternativeAuthor | 전창호 | - |
dc.contributor.AlternativeAuthor | 하동엽 | - |
dc.contributor.AlternativeAuthor | 박성준 | - |
dc.contributor.AlternativeAuthor | 이창훈 | - |
dc.contributor.AlternativeAuthor | 이상민 | - |
dc.contributor.AlternativeAuthor | 유철규 | - |
dc.contributor.AlternativeAuthor | 김영환 | - |
dc.contributor.AlternativeAuthor | 한성구 | - |
dc.contributor.AlternativeAuthor | 심영수 | - |
dc.contributor.AlternativeAuthor | 임재준 | - |
dc.identifier.doi | 10.1111/j.1440-1843.2008.01282.x | - |
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