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Efficacy of chemotherapy as a first-line treatment in ocular adnexal extranodal marginal zone B-cell lymphoma

Cited 42 time in Web of Science Cited 40 time in Scopus
Authors
Song, E. -K.; Kim, S. -Y.; Kim, T. M.; Lee, K. -W.; Yun, T.; Na, I. -I.; Shin, H.; Lee, S. H.; Kim, Dong-Wan; Khwarg, Sang In; Heo, Dae Seog
Issue Date
2008-02
Publisher
Oxford University Press
Citation
Annals of Oncology, Vol.19 No.2, pp.242-246
Keywords
chemotherapyMALT lymphomaocular adnexal lymphoma
Abstract
Background: Radiotherapy is commonly used as a first-line treatment for localized ocular adnexal extranodal marginal zone B-cell lymphoma (EMZBL), despite its ophthalmologic complications. This study was undertaken to analyze the efficacy of first-line chemotherapy in treating EMZBL. Chemotherapy was followed by radiotherapy only in recurrent cases. Patients and methods: Twenty-one patients with histologically confirmed EMZBL were treated with combination of cyclophosphamide, vincristine, and prednisolone (CVP). Radiotherapy was given to CVP failure cases. Results: CVP alone resulted in overall response rate of 100% [complete remission (CR), 76.2%]. After a median follow-up of 58 months, 14 (66.7%) of 21 cases were disease free with CVP alone, while seven cases showed disease progression, including two extra-orbital and five local failures. Radiotherapy was delivered to five local failure cases, who subsequently achieved CR with late ophthalmologic complications. There were tolerable adverse events associated with CVP. Conclusions: Front-line CVP, in conjunction with radiotherapy in recurrent cases, is effective and well tolerated in patients with localized ocular adnexal EMZBL.
ISSN
0923-7534
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17947227

http://annonc.oxfordjournals.org/cgi/reprint/19/2/242.pdf

http://hdl.handle.net/10371/68266
DOI
https://doi.org/10.1093/annonc/mdm457
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College of Medicine/School of Medicine (의과대학/대학원)Cancer Research Institute (암연구소)Journal Papers (저널논문_암연구소)
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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