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Biosensor system-on-a-chip including CMOS-based signal processing circuits and 64 carbon nanotube-based sensors for the detection of a neurotransmitter
Cited 33 time in
Web of Science
Cited 35 time in Scopus
- Authors
- Issue Date
- 2010-04
- Publisher
- Royal Society of Chemistry
- Citation
- Lab on a Chip, 2010, 10, 894-898
- Keywords
- Biosensor system ; CMOS
- Abstract
- We developed a carbon nanotube (CNT)-based biosensor system-on-a-chip (SoC) for the detection of
a neurotransmitter. Here, 64 CNT-based sensors were integrated with silicon-based signal processing
circuits in a single chip, which was made possible by combining several technological breakthroughs
such as efficient signal processing, uniform CNT networks, and biocompatible functionalization of CNTbased
sensors. The chip was utilized to detect glutamate, a neurotransmitter, where ammonia,
a byproduct of the enzymatic reaction of glutamate and glutamate oxidase on CNT-based sensors,
modulated the conductance signals to the CNT-based sensors. This is a major technological
advancement in the integration of CNT-based sensors with microelectronics, and this chip can be
readily integrated with larger scale lab-on-a-chip (LoC) systems for various applications such as LoC
systems for neural networks.
- ISSN
- 1473-0197
- Language
- English
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