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Phosphorylation of ERK1/2 and prognosis of clear cell renal cell carcinoma

Cited 10 time in Web of Science Cited 12 time in Scopus
Authors
Lee, Hyun Ju; Kim, Dong-Il; Kang, Gyeong Hoon; Kwak, Cheol; Ku, Ja Hyeon; Moon, Kyung Chul
Issue Date
2008-10-14
Publisher
Elsevier
Citation
Urology. 2009;73(2):394-399
Keywords
Carcinoma, Renal Cell/*metabolism/mortalityFemaleHumansKidney Neoplasms/*metabolism/mortalityMaleMiddle AgedMitogen-Activated Protein Kinase 3/biosynthesis/*metabolismPhosphorylationPrognosisSurvival Analysis
Abstract
OBJECTIVES: To evaluate the phosphorylation of extracellular signal-regulated kinases 1/2 (ERK1/2) in clear cell renal cell carcinoma (CCRCC) and to investigate its prognostic significance. ERK1/2 activation had been reported in RCC, but little is known about its prognostic significance. METHODS: We immunohistochemically analyzed phosphorylated ERK1/2 (pERK) expression using tissue microarrays in 328 CCRCC specimens. The percentage of tumor cells showing positive staining was evaluated and classified into 4 categories: 0, 0%; 1+, 1%-10%; 2+, 11%-50%; and 3+, > 50%. For statistical analysis, the cases were subdivided into pERK-low (0 and 1+) and pERK-high (2+ and 3+) expression. RESULTS: Our study showed significantly greater expression of pERK in CCRCC than in non-neoplastic renal parenchyma. pERK-high expression was significantly associated with a low pT category (P = .046). The survival analysis showed a significant association between pERK-high expression and better progression-free survival (P = .014). Furthermore, the prognostic significance of pERK expression was quite different between small CCRCC (size < or = 7 cm) and large CCRCC (size > 7 cm) lesions. In small CCRCC, pERK-high expression correlated significantly with better cancer-specific survival (P = .018) and better progression-free survival (P < .001). However, no correlation was found between pERK expression and survival in large CCRCC. CONCLUSIONS: High expression of pERK in CCRCC was associated with a low pT category and showed a longer progression-free survival, especially in small CCRCC. Although the biologic mechanism of the ERK pathway in CCRCC remains unknown, the results of this study suggest that pERK expression is a positive prognosticator for survival in those with small CCRCC.
ISSN
1527-9995 (Electronic)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18849062

http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6VJW-4TN5MCV-1-5&_cdi=6105&_user=168665&_orig=search&_coverDate=02%2F28%2F2009&_sk=999269997&view=c&wchp=dGLzVtb-zSkWz&md5=445ad4456c1cf1c73ffb9bc8b176b197&ie=/sdarticle.pdf

http://hdl.handle.net/10371/68373
DOI
https://doi.org/10.1016/j.urology.2008.08.472
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College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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