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Optimal Dosing of Intravenous Unfractionated Heparin Bolus in Transient Ischemic Attack or Stroke

Cited 6 time in Web of Science Cited 4 time in Scopus
Authors
Kang, Kyusik; Kim, Dong Wook; Park, Hee-Kwon; Yoon, Byung-Woo
Issue Date
2010
Publisher
Lippincott, Williams & Wilkins
Citation
Clin Appl Thromb Hemost. 2010;16(2):126-131
Abstract
Early initiation of heparin therapy for treatment of stroke is not only associated with an improved outcome, but also with the risk of hemorrhagic transformation. We compared the efficacy of three unfractionated heparin bolus regimens (0 U/kg, 30 U/kg, or 80 U/kg) in achieving a therapeutic activated partial thromboplastin time over the first 6-hour period in a cohort of 54 patients admitted with transient ischemic attack or stroke. Patients treated with the low bolus dose (30 U/kg) were more often within the therapeutic range for activated partial thromboplastin time at two hours after the initial bolus than patients treated with the other regimens. The percentage of therapeutic activated partial thromboplastin time results within the first six hours of treatment was greater in the group treated with the low bolus dose. Using the low bolus dose may reduce complication rates and improve clinical outcomes in the future clinical trials.
ISSN
1076-0296
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19117959

http://cat.sagepub.com/cgi/rapidpdf/1076029608329579v1.pdf

http://hdl.handle.net/10371/68374
DOI
https://doi.org/10.1177/1076029608329579
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Neurology (신경과학교실)Journal Papers (저널논문_신경과학교실)
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