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Gamma knife radiosurgery for skull base meningiomas: long-term radiologic and clinical outcome
DC Field | Value | Language |
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dc.contributor.author | Han, Jung Ho | - |
dc.contributor.author | Kim, Dong Gyu | - |
dc.contributor.author | Chung, Hyun-Tai | - |
dc.contributor.author | Park, Chul-Kee | - |
dc.contributor.author | Paek, Sun Ha | - |
dc.contributor.author | Kim, Chae-Yong | - |
dc.contributor.author | Jung, Hee-Won | - |
dc.date.accessioned | 2010-07-07T03:06:37Z | - |
dc.date.available | 2010-07-07T03:06:37Z | - |
dc.date.issued | 2008-10-17 | - |
dc.identifier.citation | Int J Radiat Oncol Biol Phys. 2008;72(5):1324-1332 | en |
dc.identifier.issn | 1879-355X (Electronic) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18922647 | - |
dc.identifier.uri | http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T7X-4TNTM2K-1-1&_cdi=5070&_user=168665&_orig=search&_coverDate=12%2F01%2F2008&_sk=999279994&view=c&wchp=dGLbVlb-zSkzk&md5=738106a514f34ed9ba125bc5d5fac3e8&ie=/sdarticle.pdf | - |
dc.identifier.uri | https://hdl.handle.net/10371/68404 | - |
dc.description.abstract | PURPOSE: To analyze the long-term outcomes in patients with skull base meningiomas (SBMNGs) treated with Gamma Knife radiosurgery (GKRS). METHODS AND MATERIALS: Of the 98 consecutive patients with SBMNGs treated with GKRS between 1998 and 2002, 63 were followed up for more than 48 months. The mean (+/-SD) age of the patients was 50 +/- 12 years, the mean tumor volume was 6.5 cm(3) (range, 0.5-18.4 cm(3)), the mean marginal dose was 12.6 Gy (range, 7.0-20.0 Gy), and the mean follow-up duration was 77 +/- 18 months. The mean number of shots was 13.7 +/- 3.8. The tumor volume was decreased at the last follow-up in 28 patients (44.4%) and increased in 6 (9.6%). The actuarial tumor control rate was 90.2% at 5 years. No notable prognostic factor related to tumor control was identified. Ten patients (15.9%) with a cranial neuropathy showed unfavorable outcomes. The rate of improvement in patients with a cranial neuropathy was 45.1%. Age >70 years was likely correlated with an unfavorable outcome in patients with cranial neuropathy (odds ratio = 0.027; p = 0.025; 95% confidence interval 0.001-0.632). Cavernous sinus location was significantly associated with improvement of a cranial neuropathy (odds ratio = 7.314; p = 0.007; 95% confidence interval 1.707-31.34). CONCLUSIONS: Gamma Knife radiosurgery is an effective modality for the treatment of SBMNGs and provides favorable outcomes in patients with cranial neuropathy, even in the long-term follow-up period. However, radiosurgery for patients with no or only mild symptoms should be performed cautiously because neither complication rate is low enough to be negligible, especially in elderly patients. A cranial neuropathy by MNGs involving the cavernous sinus seems to have a higher chance of improvement after radiosurgery than other SBMNGs. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Age of Onset | en |
dc.subject | Antineoplastic Combined Chemotherapy Protocols/*therapeutic use | en |
dc.subject | Child | en |
dc.subject | Child, Preschool | en |
dc.subject | Combined Modality Therapy | en |
dc.subject | Follow-Up Studies | en |
dc.subject | Humans | en |
dc.subject | Infant | en |
dc.subject | Meningeal Neoplasms/drug therapy/pathology/*surgery | en |
dc.subject | Meningioma/drug therapy/pathology/*surgery | en |
dc.subject | Recurrence | en |
dc.subject | Reoperation/statistics & numerical data | en |
dc.subject | Retrospective Studies | en |
dc.subject | Skull Base Neoplasms/drug therapy/pathology/*surgery | en |
dc.subject | Supratentorial Neoplasms/drug therapy/pathology/*surgery | en |
dc.subject | Time Factors | en |
dc.subject | Treatment Outcome | en |
dc.subject | Radiosurgery/methods | - |
dc.title | Gamma knife radiosurgery for skull base meningiomas: long-term radiologic and clinical outcome | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 한정호 | - |
dc.contributor.AlternativeAuthor | 김동규 | - |
dc.contributor.AlternativeAuthor | 정현태 | - |
dc.contributor.AlternativeAuthor | 박철기 | - |
dc.contributor.AlternativeAuthor | 백선하 | - |
dc.contributor.AlternativeAuthor | 김재용 | - |
dc.contributor.AlternativeAuthor | 정희원 | - |
dc.identifier.doi | 10.1016/j.ijrobp.2008.03.028 | - |
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