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Galantamine reduces striatal degeneration in 3-nitropropionic acid model of Huntington's disease

Cited 11 time in Web of Science Cited 14 time in Scopus
Authors
Park, Jung-Eun; Lee, Soon-Tae; Im, Woo-Seok; Chu, Kon; Kim, Manho
Issue Date
2008-10-22
Publisher
Elsevier
Citation
Neurosci Lett. 448 (2008) 143-147
Keywords
Analysis of VarianceAnimalsCorpus Striatum/drug effects/pathologyDisease Models, AnimalDose-Response Relationship, DrugGalantamine/*therapeutic useHuntington Disease/chemically induced/*complicationsIn Situ Nick-End Labeling/methodsMaleNerve Degeneration/*drug therapy/etiology/*pathologyNeurologic ExaminationNitro CompoundsNootropic Agents/*therapeutic usePropionic AcidsRatsRats, Inbred LewStatistics, Nonparametric
Abstract
The acetylcholinesterase inhibitor (AChEI) galantamine is currently used to treat mild to moderate Alzheimer's disease (AD), and it has been suggested to have several neuroprotective effects. To investigate the potential application of this drug to the treatment of Huntington's disease, we examined whether galantamine can reduce the striatal degeneration induced by the mitochondrial toxin, 3-nitropropionic acid (3NP). 3NP (63 mg/kg/day) was delivered to Lewis rats by osmotic pumps for 5 consecutive days, and the rats received intraperitoneal administration of either different concentrations of galantamine (1mg/kg/day or 10 mg/kg/day, twice daily) or vehicle (saline) throughout the experiment. Galantamine attenuated the 3NP-induced neurologic deficits on days 2-5. Galantamine-treated rats showed smaller striatal lesion volumes measured by Nissl staining and lower numbers of TUNEL(+) apoptotic cells when compared to the vehicle-treated rats. Galantamine failed to reduce the striatal lesion volume when co-administered with mecamylamine, a nicotinic acetylcholine receptor antagonist. Our data indicate that galantamine can attenuate neurodegeneration in a Huntington's disease model by modulating nAChR.
ISSN
0304-3940 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18938211

http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T0G-4TNWH31-7-9&_cdi=4862&_user=168665&_orig=search&_coverDate=12%2F19%2F2008&_sk=995519998&view=c&wchp=dGLzVtb-zSkzV&md5=e823816718ff5f02a22f1ad460720d10&ie=/sdarticle.pdf

http://hdl.handle.net/10371/68459
DOI
https://doi.org/10.1016/j.neulet.2008.10.020
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Neurology (신경과학교실)Journal Papers (저널논문_신경과학교실)
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