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Simulation of Ca2+-activated Cl- current of cardiomyocytes in rabbit pulmonary vein: implications of subsarcolemmal Ca2+ dynamics
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Leem, Chae Hun | - |
dc.contributor.author | Kim, Won Tae | - |
dc.contributor.author | Ha, Jeong Mi | - |
dc.contributor.author | Lee, Yoon Jin | - |
dc.contributor.author | Seong, Hyeon Chan | - |
dc.contributor.author | Choe, Han | - |
dc.contributor.author | Jang, Yeon Jin | - |
dc.contributor.author | Youm, Jae Boum | - |
dc.contributor.author | Earm, Yung E | - |
dc.date.accessioned | 2010-07-07T23:32:57Z | - |
dc.date.available | 2010-07-07T23:32:57Z | - |
dc.date.issued | 2006-04-13 | - |
dc.identifier.citation | Philos Transact A Math Phys Eng Sci. 364(1842), 1223-1243 | en |
dc.identifier.issn | 1364-503X (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16608705 | - |
dc.identifier.uri | https://hdl.handle.net/10371/68471 | - |
dc.description.abstract | In recent studies, we recorded transiently activated outward currents by the application of three-step voltage pulses to induce a reverse mode of Na+-Ca2+ exchange (NCX). We found that these currents were mediated by a Ca2+-activated Cl- current. Based on the recent reports describing the atrial Ca2+ transients, the Ca2+ transient at the subsarcolemmal space was initiated and then diffused into the cytosolic space. Because the myocardium in the pulmonary vein is an extension of the atrium, the Ca2+-activated Cl- current may reflect the subsarcolemmal Ca2+ dynamics. We tried to predict the subsarcolemmal Ca2+ dynamics by simulating these current traces. According to recent reports on the geometry of atrial myocytes, we assumed that there were three compartments of sarcoplasmic reticulum (SR): a network SR, a junctional SR and a central SR. Based on these structures, we also divided the cytosolic space into three compartments: the junctional, subsarcolemmal and cytosolic spaces. Geometry information and cellular capacitance suggested that there were essentially no T-tubules in these cells. The basic physical data, such as the compartmental volumes, the diffusion coefficients and the stability coefficients of the Ca2+ buffers, were obtained from the literature. In the simulation, we incorporated the NCX, the L-type Ca2+ channel, the rapid activating outward rectifier K+ channel, the Na+-K+ pump, the SR Ca2+-pump, the ryanodine receptor, the Ca2+-activated Cl- channel and the dynamics of Na+, K+, Ca2+ and Cl-. In these conditions, we could successfully reconstruct the Ca2+-activated Cl- currents. The simulation allowed estimation of the Ca2+ dynamics of each compartment and the distribution of the Ca2+-activated Cl- channel and the NCX in the sarcolemma on the junctional or subsarcolemmal space. | en |
dc.language.iso | en | en |
dc.publisher | Royal Society, The | en |
dc.subject | Action Potentials/*physiology | en |
dc.subject | Animals | en |
dc.subject | Calcium/*metabolism | en |
dc.subject | Calcium Signaling/physiology | en |
dc.subject | Cells, Cultured | en |
dc.subject | Chlorine/*metabolism | en |
dc.subject | Computer Simulation | en |
dc.subject | Membrane Potentials/physiology | en |
dc.subject | Myocytes, Cardiac/*physiology | en |
dc.subject | Pulmonary Veins/cytology/*physiology | en |
dc.subject | Rabbits | en |
dc.subject | Sarcolemma/*physiology | en |
dc.subject | Models, Cardiovascular | - |
dc.title | Simulation of Ca2+-activated Cl- current of cardiomyocytes in rabbit pulmonary vein: implications of subsarcolemmal Ca2+ dynamics | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 임채훈 | - |
dc.contributor.AlternativeAuthor | 김원태 | - |
dc.contributor.AlternativeAuthor | 하정미 | - |
dc.contributor.AlternativeAuthor | 이윤진 | - |
dc.contributor.AlternativeAuthor | 성현찬 | - |
dc.contributor.AlternativeAuthor | 최한 | - |
dc.contributor.AlternativeAuthor | 장연진 | - |
dc.contributor.AlternativeAuthor | 염재범 | - |
dc.contributor.AlternativeAuthor | 엄융의 | - |
dc.identifier.doi | 10.1098/rsta.2006.1766 | - |
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