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Intracoronary continuous adenosine infusion

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Authors
Koo, Bon-Kwon; Kim, Cheol-Ho; Na, Sang-Hun; Youn, Tae-Jin; Chae, In-Ho; Choi, Dong-Ju; Kim, Hyo-Soo; Lee, Myoung-Mook; Oh, Byung-Hee; Park, Young-Bae; Choi, Yun-Shik; Tahk, Seung-Jae
Issue Date
2005-07-26
Publisher
The Japanese Circulation Society
Citation
Circ J. 2005;69(8): 908-912
Keywords
Adenosine/*administration & dosageAgedBlood Flow Velocity/drug effectsCoronary Circulation/*drug effects*Coronary Stenosis/drug therapyFemaleHumansHyperemia/*chemically inducedInfusions, Intra-ArterialMaleMiddle Aged
Abstract
BACKGROUND: Various methods are used to induce maximal hyperemia for physiologic studies, but the feasibility and efficacy of continuous intracoronary (IC) infusion of adenosine for measurement of fractional flow reserve (FFR) has not been well-defined. METHODS AND RESULTS: Patients with intermediate coronary artery stenosis were consecutively enrolled. In the phase I study, FFR was measured after 3 dosages of IC adenosine infusion (180, 240 and 300 microg/min) in 30 patients. The phase II study was performed to compare the hyperemic efficacy of IC infusion (240 microg/min) with IC bolus injection (40, 80 microg) and intravenous (IV) infusion (140 microg x kg (-1) x min(-1)) of adenosine in 20 patients. In the phase I study, no significant differences in FFR were observed with the 3 different doses of IC infusion (p = 0.06). In the phase II study, FFR after an IC bolus injection (0.83+/-0.06) was significantly higher than with IV (0.79+/-0.07) or IC (0.78+/-0.09) infusion (p < 0.01). However, no difference in FFR was observed for IC and IV infusions. CONCLUSION: IC infusion of adenosine seems to be a safe and effective method of inducing maximal hyperemia for FFR measurement.
ISSN
1346-9843 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16041158

http://hdl.handle.net/10371/68475
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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