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β-amyloid peptide binding protein does not couple to G protein in a heterologous Xenopus expression system
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Yong | - |
dc.contributor.author | Chang, Deok-Jin | - |
dc.contributor.author | Lee, Yong-Seok | - |
dc.contributor.author | Chang, Keun-A | - |
dc.contributor.author | Kim, Hyoung | - |
dc.contributor.author | Yoon, Jeung-Sook | - |
dc.contributor.author | Lee, Seungbok | - |
dc.contributor.author | Suh, Yoo-Hun | - |
dc.contributor.author | Kang, Bong-Kiun | - |
dc.date.accessioned | 2010-08-03T23:34:28Z | - |
dc.date.available | 2010-08-03T23:34:28Z | - |
dc.date.issued | 2003 | - |
dc.identifier.citation | Journal of Neuroscience Research 73:255–259 | en |
dc.identifier.issn | 0360-4012 | - |
dc.identifier.uri | https://hdl.handle.net/10371/68907 | - |
dc.description.abstract | Alzheimer's disease is a neurodegenerative disorder related to the formation of protein aggregates. -Amyloid protein (A), generated by enzymatic cleavage of amyloid precursor protein (APP), can cause such aggregation, and these aggregates may cause neuronal cell death by inducing apoptosis. However, A-induced intracellular signaling pathways involved in the neuronal death are not well understood. Recently it was shown that A aggregates induce neuronal cell death via -amyloid peptide-binding protein (BBP), a receptor for A in BBP-transfected cells, which is known to be sensitive to pertussis toxin, a Gi/o family inhibitor. However, the actual coupling of BBP to the pertussis-sensitive G protein was not demonstrated. In this study, we performed electrophysiological recordings using the two-electrode voltage-clamp technique to test whether human or Drosophila BBPs, singly or in combination with APP, are coupled to a specific type of G protein. Our results suggest that BBP is not directly coupled to Gi/o, Gs, or Gq proteins and that BBP may need a component other than APP to exert its toxic effect in concert with Aβ. | en |
dc.description.sponsorship | Y. L. and Y.-S. L. were supported by BK21 Research
Fellowship from the Korea Ministry of Education and Human Resources Development. | en |
dc.language.iso | en | en |
dc.publisher | Wiley-Blackwell | en |
dc.subject | Alzheimer's disease | en |
dc.subject | β-amyloid peptide binding protein | en |
dc.subject | amyloid precursor protein | en |
dc.subject | G protein | en |
dc.title | β-amyloid peptide binding protein does not couple to G protein in a heterologous Xenopus expression system | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 이용 | - |
dc.contributor.AlternativeAuthor | 장덕진 | - |
dc.contributor.AlternativeAuthor | 이용석 | - |
dc.contributor.AlternativeAuthor | 장근아 | - |
dc.contributor.AlternativeAuthor | 윤정숙 | - |
dc.contributor.AlternativeAuthor | 이승복 | - |
dc.contributor.AlternativeAuthor | 서유훈 | - |
dc.identifier.doi | 10.1002/jnr.10652 | - |
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