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Induction of human umbilical cord blood-derived stem cells with embryonic stem cell phenotypes into insulin producing islet-like structure
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sun, Bo | - |
dc.contributor.author | Roh, Kyung-Hwan | - |
dc.contributor.author | Lee, Sae-Rom | - |
dc.contributor.author | Lee, Yong Soon | - |
dc.contributor.author | Kang, Kyung-Sun | - |
dc.date.accessioned | 2009-08-11T22:35:58Z | - |
dc.date.available | 2009-08-11T22:35:58Z | - |
dc.date.issued | 2007-01-24 | - |
dc.identifier.citation | Biochem Biophys Res Commun 354 (2007) 919-923 | en |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://hdl.handle.net/10371/6957 | - |
dc.description.abstract | Success in islet-transplantation-based therapies for type I diabetes, coupled with a worldwide shortage of transplant-ready islets, has motivated efforts to develop renewable sources of islet-replacement tissue. Embryonic stem cells (ESCs) have been successfully induced into insulin producing islet-like structure in several studies. However, the source of the ESCs has presented ethical and technical concerns. Here, we isolated a population of stem cells from human cord blood (UCB), which expressed embryo stage specific maker, SSEA-4, and the multi-potential stem cell marker, Oct4. Subsequently, we successfully induced them into insulin-producing islet-like structures, which co-express insulin and C-peptide. These findings might have a significant potential to advance human UCB derived stem-cell-based therapeutics for diabetes. | en |
dc.description.sponsorship | This work was supported by the Seoul R&BD program (#10548) and also supported by a grant BK21 program for veterinary science. Further support was provided by Invitation and Training of Outstanding Overseas Student Researchers Program (2004) of Korean Research Foundation. We appreciate the great contributions of Dr. James E. Trosko (National Food Safety Toxicology Center, Department of Pediatrics and Human Development, Michigan State University, East Lansing, MI 48824, USA), who helped to revise and fully discussed on this manuscript | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Stem cells | en |
dc.subject | Human umbilical cord blood | en |
dc.subject | Islet-like structure differentiation | en |
dc.subject | Insulin producing cells | en |
dc.title | Induction of human umbilical cord blood-derived stem cells with embryonic stem cell phenotypes into insulin producing islet-like structure | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 노경환 | - |
dc.contributor.AlternativeAuthor | 이새롬 | - |
dc.contributor.AlternativeAuthor | 이영순 | - |
dc.contributor.AlternativeAuthor | 강경선 | - |
dc.identifier.doi | 10.1016/j.bbrc.2007.01.069 | - |
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