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Signaling pathways of the early differentiation of neural stem cells by neurotrophin-3
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lim, Myung-Shin | - |
dc.contributor.author | Nam, Sang-Hyun | - |
dc.contributor.author | Kim, Sun-Jung | - |
dc.contributor.author | Kang, Seog-Youn | - |
dc.contributor.author | Lee, Yong Soon | - |
dc.contributor.author | Kang, Kyung-Sun | - |
dc.date.accessioned | 2009-08-11T22:37:19Z | - |
dc.date.available | 2009-08-11T22:37:19Z | - |
dc.date.issued | 2007-04-18 | - |
dc.identifier.citation | Biochem. Biophys. Res. Commun. 357 (2007) 903-909 | en |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://hdl.handle.net/10371/6959 | - |
dc.description.abstract | Neurotrophin-3 (NT-3) is well known to play an important role in facilitating neuronal survival and differentiation during development. However, the mechanisms by which neurotrophin-3 promotes prolonged Akt/MAPK signaling at an early stage are not well understood. Here, we report that NT-3 works at an early stage of neuronal differentiation in mouse neural stem cells (NSCs). After treatment with NT-3 for 12 h, more NSCs differentiated into neurons than did untreated cells. These findings demonstrated that stimulation with NT-3 causes NSCs to differentiate into neurons through a phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway and the phosphorylated extracellular signal-regulated kinase (ERK) pathway. In addition, treatment with NT-3 induced neurite outgrowth by specific phosphorylation of p38 MAPK, which was accompanied by neuronal differentiation. Taken together, these results suggest that NT-3, along with the Trk C receptors in NSCs, might lead to the survival and neuronal differentiation of NSCs via two distinct downstream signaling pathways at an early stage of neuronal differentiation. | en |
dc.description.sponsorship | This work was supported by a grant from the Korean Science & Engineering Foundation (R01-2005-000-10190-0). | en |
dc.language.iso | en | - |
dc.publisher | Elsevier | en |
dc.subject | Neural stem cells | en |
dc.subject | Neurotrophin-3 | en |
dc.subject | Neuronal differentiation | en |
dc.subject | Neurite outgrowth | en |
dc.subject | Akt | en |
dc.subject | ERK | en |
dc.subject | p38 | en |
dc.title | Signaling pathways of the early differentiation of neural stem cells by neurotrophin-3 | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 임명신 | - |
dc.contributor.AlternativeAuthor | 남상현 | - |
dc.contributor.AlternativeAuthor | 김선정 | - |
dc.contributor.AlternativeAuthor | 강석연 | - |
dc.contributor.AlternativeAuthor | 이영순 | - |
dc.contributor.AlternativeAuthor | 강경선 | - |
dc.identifier.doi | 10.1016/j.bbrc.2007.04.045 | - |
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