Publications
Detailed Information
The bone regenerative effect of platelet derived growth factor-BB delivered with a chitosan/tricalcium phospahate matrix carrier
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ku, Young | - |
dc.contributor.author | Lee, Yong-Moo | - |
dc.contributor.author | Park, Yoon-Jeong | - |
dc.contributor.author | Lee, Seung-Jin | - |
dc.contributor.author | Han, Soo-Boo | - |
dc.contributor.author | Klokkevold, Perry R | - |
dc.contributor.author | Chung, Chong-Pyoung | - |
dc.date.accessioned | 2010-09-03T04:03:24Z | - |
dc.date.available | 2010-09-03T04:03:24Z | - |
dc.date.issued | 2000 | - |
dc.identifier.citation | Journal of Periodontology 2000;71:418-424 | en |
dc.identifier.issn | 0022-3492 | - |
dc.identifier.uri | https://hdl.handle.net/10371/69635 | - |
dc.description.abstract | Background: In order to achieve optimal effects, growth factors including platelet-derived growth factor (PDGF) should be delivered with a biodegradable carrier that will release therapeutic concentrations over a sufficient length of time. The purpose of this study was to evaluate the bone regenerative effect of PDGF-BB delivered with a chitosan/tricalcium phosphate (TCP) sponge carrier in a rat calvarial defect model.
Methods: The PDGF-BB–loaded chitosan/TCP sponge carrier was fabricated by freeze-drying a mixture of chitosan solution and TCP powder and soaking in a PDGF-BB solution. The release kinetics of PDGF-BB loaded onto the sponge were measured in vitro with 125I-labeled PDGF-BB. Chitosan/TCP sponges with and without PDGF-BB were implanted into 8 mm calvarial defects in rats. Rats were sacrificed at 2 and 4 weeks following implantation, and histologic and histomorphometrical examinations were performed.c Results: In vitro evaluation demonstrated that an effective therapeutic concentration of PDGF-BB following a high initial burst release was maintained throughout the examination period. In the histologic examination, the chitosan/TCP sponge carrier promoted osseous healing of the rat calvarial defects as compared to controls. The addition of PDGF-BB to the carrier further enhanced bone regeneration. Evidence of the degraded sponge matrix was observed mingled within the newly formed bone without connective tissue encapsulation. Conclusions: The results of this study support the use of chitosan/ TCP sponges as a delivery system for growth factors and demonstrate that PDGF-BB loaded onto chitosan/TCP sponge carriers has an osteogenic effect on bone regeneration in vivo. J Periodontol 2000;71:418-424. | en |
dc.language.iso | en | en |
dc.publisher | American Academy of Periodontology | en |
dc.subject | Bone regeneration | en |
dc.subject | animal studies | en |
dc.subject | bone development | en |
dc.subject | chitosan | en |
dc.subject | growth factors | en |
dc.subject | platelet-derived | en |
dc.subject | tricalcium phosphate | en |
dc.subject | sponges | en |
dc.subject | artificial | en |
dc.subject | tissue engineering | en |
dc.title | The bone regenerative effect of platelet derived growth factor-BB delivered with a chitosan/tricalcium phospahate matrix carrier | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 구영 | - |
dc.contributor.AlternativeAuthor | 이용무 | - |
dc.contributor.AlternativeAuthor | 박연정 | - |
dc.contributor.AlternativeAuthor | 이승진 | - |
dc.contributor.AlternativeAuthor | 한수부 | - |
dc.contributor.AlternativeAuthor | 정종평 | - |
dc.identifier.doi | 10.1902/jop.2000.71.3.418 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.