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Thickness and microhardness of deciduous tooth enamel with known DLX3 mutation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hyun, Hong-Keun | - |
dc.contributor.author | Kim, Jung-Wook | - |
dc.date.accessioned | 2010-09-06 | - |
dc.date.available | 2010-09-06 | - |
dc.date.issued | 2009-09 | - |
dc.identifier.citation | Archives of Oral Biology 2009;54:830-834 | en |
dc.identifier.issn | 0003-9969 | - |
dc.identifier.uri | https://hdl.handle.net/10371/69718 | - |
dc.description.abstract | Aim
To investigate the thickness and hardness of teeth affected by a 2-bp deletion (c.561_562delCT) in the DLX3 gene. Methods and materials Extracted maxillary deciduous second molar was collected from the affected individual at age 12 years 7 months. Samples were sectioned buccolingually after embedding in epoxy resin. We measured the enamel thickness and microhardness and performed an elemental analysis using an electron probe microanalyser. Results On average, the hardness of the enamel with a 2-bp deletion in DLX3 was about 53% of normal enamel hardness. The mutant enamel thickness was about half of the thickness of the normal control. The calcium level in the enamel with the 2-bp deletion was slightly decreased, while the magnesium level was slightly increased, in comparison to levels measured for normal teeth. Conclusion This study shows that enamel affected by a 2-bp deletion in DLX3 has reduced thickness as well as diminished microhardness. These data may explain the severe attrition and interdental spacing observed in affected individuals. | en |
dc.description.sponsorship | This work was supported by a grant from the Korea Health
21 R&D Project, Ministry of Health & Welfare, Republic of Korea (A060010), a grant from the Korea Science and Engineering Foundation (KOSEF) through the Biotechnology R&D program (No. M10646010003-08N4601-00310), and a grant from the Korea Science and Engineering Foundation (KOSEF) Science Research Center funded by the Korean Ministry of Education, Science and Technology (MEST) through the Bone Metabolism Research Center (No. R11- 2008-023-02003-0). | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Enamel | en |
dc.subject | DLX3 | en |
dc.subject | Thickness | en |
dc.subject | Microhardness | en |
dc.subject | Mutation | en |
dc.title | Thickness and microhardness of deciduous tooth enamel with known DLX3 mutation | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 현홍근 | - |
dc.contributor.AlternativeAuthor | 김정욱 | - |
dc.identifier.doi | 10.1016/j.archoralbio.2009.06.005 | - |
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