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Efficacy of sulforaphane is mediated by p38 MAP kinase and caspase-7 activations in ER-positive and COX-2-expressed human breast cancer cells

DC Field Value Language
dc.contributor.authorJo, Eun-Hye-
dc.contributor.authorKim, Sung-Hoon-
dc.contributor.authorAhn, Nam-Shik-
dc.contributor.authorPark, Joon-Suk-
dc.contributor.authorHwang, Jae-Woong-
dc.contributor.authorLee, Yong Soon-
dc.contributor.authorKang, Kyung-Sun-
dc.date.accessioned2009-08-11T22:56:09Z-
dc.date.available2009-08-11T22:56:09Z-
dc.date.issued2007-
dc.identifier.citationEur J Cancer Prev 16:505-510en
dc.identifier.issn0959-8278 (print)-
dc.identifier.issn1473-5709 (online)-
dc.identifier.urihttp://hdl.handle.net/10371/6972-
dc.description.abstractSulforaphane is an antioxidant and a potent stimulator of natural detoxifying enzyme and associated with lowered risk of cancer that is associated with the consumption of cruciferous vegetables. The chemopreventive effects of SFN was investigated using the MCF-7 human breast cancer cells and the M13SV1-immortalized human breast luminal epithelial cells. Sulforaphane reduced proliferation in MCF-7 cells and inhibited cyclooxygenase-2 expression in M13SV1 cells treated with 12-O-tetradecanoylphorbol-13-acetate (TPA). The chemopreventive effects of sulforaphane were associated with p38 mitogen-activated protein kinase suggest its important role in cell survival/apoptosis regulation and stabilization of cyclooxygenase-2. Sulforaphane upregulates p38 in MCF-7 cells and prevented TPA-reduced phosphorylation of p38 in M13SV1 cells, but activated caspase-7 associated with apoptosis in MCF-7 cells. These results suggest that sulforaphane may be an alternative candidate for targeted prevention of ER-positive and cyclooxygenase-2-induced phenotypes and breast cancer.en
dc.description.sponsorshipThis study is supported by Korea Research Foundation Grant
(KRF-005-E00076), and also by BK 21 Program for Veterinary and Biogreen21
program, Republic of Korea.
en
dc.language.isoen-
dc.publisherLippincott, Williams & Wilkinsen
dc.subjectcaspase-7en
dc.subjectchemopreventionen
dc.subjecthuman breast canceren
dc.subjectMAPKen
dc.subjectsulforaphaneen
dc.titleEfficacy of sulforaphane is mediated by p38 MAP kinase and caspase-7 activations in ER-positive and COX-2-expressed human breast cancer cellsen
dc.typeArticleen
dc.contributor.AlternativeAuthor조은혜-
dc.contributor.AlternativeAuthor김성훈-
dc.contributor.AlternativeAuthor안남식-
dc.contributor.AlternativeAuthor박준석-
dc.contributor.AlternativeAuthor황재웅-
dc.contributor.AlternativeAuthor이영순-
dc.contributor.AlternativeAuthor강경선-
dc.identifier.doi10.1097/01.cej.0000243856.97479.3b-
Appears in Collections:
College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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