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Genitourinary Rhabdomyosarcoma with Systemic Metastasis in a Young Dog

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Authors
Bae, I.-H.; Kim, Y.; Parkhrin, B.; You, Mi-Hyeon; Hwang, Cheol Yong; Kim, J.-H.; Kim, Dae-Yong
Issue Date
2007
Publisher
American College of Veterinary Pathologists
Citation
Vet Pathol 44:518-520, 2007
Keywords
Dogsrhabdomyosarcomasarcoma botryoidesurinary bladderuterus
Abstract
A 2-year-old intact female Golden Retriever presented due to rapidly progressing depression, ascites, dysuria, abdominal pain, and severe vaginal bleeding. At necropsy, the retroperitoneal space was expanded by multiple coalescing neoplastic nodules and the uterine wall was thickened with poorly defined neoplastic infiltrates. The urinary bladder was markedly thickened due to botryoid nodules exhibiting exophytic growth into the lumen. Metastases to lung, liver, kidney, and abdominal and thoracic lymph nodes were also noted. Microscopically, the genital tract and retroperitoneal masses were consistent with the alveolar subtype of rhabdomysarcoma, while the urinary bladder mass had characteristics of the embryonal subtype. Immunohistochemically, the neoplastic cells in all these tissue sites were intensely positive for desmin, sacromeric actin, and vimentin, while they were uniformly negative for cytokeratin and smooth muscle actin. Phosphotungstic acid hematoxylin stain revealed cross-striations in the cytoplasm of scattered neoplastic cells. Based on the gross findings, histopathology, and immunohistochemistry, genitourinary rhabdomyosarcoma with multisystemic metastases was made.
ISSN
0300-9858
Language
English
URI
http://www.vetpathology.org/cgi/content/full/44/4/518

http://hdl.handle.net/10371/6975
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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