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"Immunoregulatory effects of extracts from the stem bark of Albizzia julibrissin Durazz

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dc.contributor.authorChoi, Youngnim-
dc.contributor.authorKim, Jeong J-
dc.contributor.authorLee, Byung E-
dc.contributor.authorJung, Dong S-
dc.contributor.authorKim, Se Won-
dc.contributor.authorKo, Seon Yle-
dc.contributor.authorBaek, Dong Heon-
dc.contributor.authorChang, Sun Hwa-
dc.date.accessioned2010-09-09T06:20:45Z-
dc.date.available2010-09-09T06:20:45Z-
dc.date.issued2004-12-
dc.identifier.citationInternational Journal of Oral Biology 29:137-144en
dc.identifier.issn1226-7155-
dc.identifier.urihttp://hdl.handle.net/10371/69784-
dc.description.abstractAlthough there are many disease modifying antirheumatic drugs (DMARDs) available, more safe and effective reagents have yet to be developed. Activated T cells make good targets for DMARD therapy. Therefore, we screened over fifty herbal extracts, and identified that water extract from the stem bark of Albizzia julibrissin selectively killed activated T cells but not naive splenocytes, in vitro. Wb3-3, obtained by further extraction and column chromatography to maximize selective activity, was used for further investigation. Annexin-V and caspase activity assay revealed that WB3-3 killed activated T cells by inducing apoptosis, which was mediated through mainly caspase-8 rather than caspase-9. The effect of WB3-3 in vivo was conlirmed by the elimination of V8- but no V6-T cells following activation with Streptococcal Enterotoxin B (SEB). Furthermore, WB3-3 inhibited neither CD25 upregulationnor proliferative response, and rather increased IL-2 secretion during Con A activation of naive T cells.Our results imply the potential of WB3-3 to include a lead compound for a new immunoregulatory drug.en
dc.language.isoenen
dc.publisherKorean Acadamy of Oral Biologyen
dc.subjectdisease modifying anti-rheumatic(DMARD)en
dc.subjectalbizzia julibrissinen
dc.subjectactivated T cellen
dc.subjectapoptosisen
dc.subjectcaspase-8en
dc.title"Immunoregulatory effects of extracts from the stem bark of Albizzia julibrissin Durazzen
dc.typeArticleen
dc.contributor.AlternativeAuthor최영님-
dc.contributor.AlternativeAuthor김세원-
dc.contributor.AlternativeAuthor고선일-
dc.contributor.AlternativeAuthor백동헌-
dc.contributor.AlternativeAuthor장선화-
Appears in Collections:
College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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