Browse

Altered cortical synaptic morphology and impaired memory consolidation in forebrain-specific dominant-negative PAK transgenic mice

Cited 207 time in Web of Science Cited 218 time in Scopus
Authors
Hayashi, Mansuo L; Choi, Se-Young; Rao, B.S.Shankaranarayana; Jung, Hae-Yoon; Lee, Hey-Kyoung; Zhang, Dawei; Chattarji, Sumantra; Kirkwood, Alfredo; Tonegawa, Susumu
Issue Date
2004-06
Publisher
Elsevier
Citation
Neuron 42, 773-787
Abstract
Molecular and cellular mechanisms for memory consolidation in the cortex are poorly known. To study the relationships between synaptic structure and function in the cortex and consolidation of long-term memory, we have generated transgenic mice in which catalytic activity of PAK, a critical regulator of actin remodeling, is inhibited in the postnatal forebrain. Cortical neurons in these mice displayed fewer dendritic spines and an increased proportion of larger synapses compared to wild-type controls. These alterations in basal synaptic morphology correlated with enhanced mean synaptic strength and impaired bidirectional synaptic modifiability (enhanced LTP and reduced LTD) in the cortex. By contrast, spine morphology and synaptic plasticity were normal in the hippocampus of these mice. Importantly, these mice exhibited specific deficits in the consolidation phase of hippocampus-dependent memory. Thus, our results provide evidence for critical relationships between synaptic morphology and bidirectional modifiability of synaptic strength in the cortex and consolidation of long-term memory.
ISSN
0896-6273
Language
English
URI
http://hdl.handle.net/10371/69797
DOI
https://doi.org/10.1016/j.neuron.2004.05.003
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse