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Evaluation of a rapid immunodiagnostic test kit for rabies virus

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Authors
Kang, BoKyu; Oh, JinSik; Lee, ChulSeung; Park, BongKyun; Park, YoungNam; Hong, KyungSoo; Lee, KyungGi; Cho, ByungKi; Song, DaeSub
Issue Date
2007-07-12
Publisher
Elsevier
Citation
J. Virol. Met. 145, 30-36
Keywords
Rapid immunodiagnostic testRabiesSensitivitySpecificity
Abstract
A rapid immunodiagnostic test kit for rabies virus detection was evaluated using 51 clinical samples and 4 isolates of rabies virus. The quick detection of rabies virus under field conditions may be helpful in determining if post-exposure prophylaxis is needed, thereby avoiding unnecessary treatments, as well as undue economic burden. There are several widely used diagnostic methods for rabies, including fluorescent antibody tests, reverse transcription polymerase chain reaction, and electron microscopy; however, these methods include time-consuming, intricate, and costly procedures. The rapid immunodiagnostic test was able to detect rabies virus in clinical samples, including brain tissue and saliva, in addition to 103.2 50% lethal dose (LD50)/mL cell-adapted rabies virus. The assay was not cross-reactive with non-rabies virus microbes. When the performance of the rapid immunodiagnostic test was compared to a fluorescent antibody test, the rapid immunodiagnostic test had a sensitivity of 91.7% and specificity of 100% (95.8% CI).
ISSN
0166-0934
Language
English
URI
http://hdl.handle.net/10371/7038
DOI
https://doi.org/10.1016/j.jviromet.2007.05.005
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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