SHERP

각종 질환에 있어서의 HLA빈도에 관한 연구
A Study on the Frequency of HLA Antigens in Varions Diseases

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Authors
이순용; 고광욱; 최규완
Issue Date
1976-09
Publisher
서울대학교 의과대학
Citation
Seoul J Med 1976;17(3):159-170
Abstract
The purpose of this study is to investigate distribution
of the HLA antigens among Korean population
and to elucidate any correlation between the HLA
antigens and various human diseases. The subjects
for this study consisted of 85 normal healthy persons,
28 patients with stomach cancer, 24 with liver cancer,
and 32 with pulmonary tuberculosis. The diagnosis of
cancer was confirmed either by the radiological, endo
scopic, serologic or histopathologic findings, and patients
with pulmonary tuberculosis included only those
who had moderate advanced or far advanced pulmonary
tuberculosis. The detection of HLA antigens was
carried out with the micortoxicity test devised by Tcrasaki,
the lymphocytes being seperated from peripheral
blood by density-gradient centrifugation in the
Ficoll-Hypaque solution. The standard HLA antiserum
used in this study was the T-serics antiserum provided
by the Beringwerke company, West Germany.
The antiserum included HLA-A 1, 2, 3, 9,10.11, and
HLA-B 5,7,8,12. The positive and negative control
sera were also used.
The observed data are summarized as follows:
1. The detection rate of the HLA antigens was
essentially the same among normal healthy persons.
and patients with stomach cancer, liver cancer, and
pulmonary tuberculosis.
2. In the normal control group, HLA·A2 and A3
were most frequently detected in the first segregation
series, and HLA-B 12 and B 7 in the second segregation
series, respectively.
3. In the group of stomach cancer, the most frequent
HLA antigens were HLA-A2 and AIO in the first
segregation series, and IlLA-B5 and B8 in the second
segregation series, respectively. As compared with
normal control group, IlLA-AIO was slightly increased
and HLA-BI2 were markedly reduced in frequency
among the patients with stomach cancer.
4. In the group of the liver cancer, the most frequent
HLA antigens were HLA-A2 and AIO in the first
segregation series, and HLA-B8 and BI2 in the second
segregation series. As compared with the normal
control group, the HLA-B7 was markedly reduced in
frequency in the patients with liver cancer.
5. In the patients with pulmonary tuberculosis, the most frequent HLA autigens were HLA-A2 and AIO
in the first segregation series, and HLA-B5 and Bl2
in the second segregation series. As compared with the
normal control group, HLA-B7 was slightly reduced
and HLA-BI2 was markedly reduced in frequency in
the patients with pulmonary tubeculosis.
Language
Korean
URI
http://hdl.handle.net/10371/7182
Files in This Item:
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 17 No.3 (1976)
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