일부 무의촌지역과 병원에서 분리한 K. pneumoniae의 항균제 감수성에 관한 연구

Abstract

58 strains of K. pneumoniae isolated from residents of doctor!ess areas in Korea from 1976 to 1977 and 67 strains of K. pneumoniae isolated from patients of Seoul National University Hospital from 1975 to 1977 were examined for susceptibility to 14 antimicrobics by agar dilution method. The susceptibility of two groups to each antimicrobics were compared and incidence of resistant strains in each antimicrobics, incidence of multiple resistant strains and correlations in the antimicrobic susceptibility of 125 strains of K. pneumoniae among 14 antimicrobics were analyzed. The results obtained were as follows. 1. The mean MIC of Ampicillin, Tetracyline, Oxytetracycline, Kanamycin and Streptomycin to the K. pneumoniae isolated from patients of Seoul National University Hospital were 2. 1 to 2.8 times higher than those to the K. pneumoniae isolated from residents of doctorless areas. 2. The mean MIC of Penicillin, Doxycycline and Cotrimoxazole to the K. pneumoniae isolated from patients of Seoul National University Hospital were 1. 4 to 1. 7 times higher than those to the K. pneumoniae isolated from residents of doctorless areas. 3. Tl:ere wcre no significant differences in suscep· tibility to Carbenicillin, Cephalexin, Minocycline, Gentamicin, and Erythromycin respectively between K. pneumoniae isolated from patients of Seoul Nationa! University Hospital and those from residents of doctorless arease. 4. Incidence of resistant strains In K. pneumoniae isolated from Seoul National University Hospital was the highest with Troleandomycin (100%) and Erythromycin (100%) followed by Carbenicillin (94.0%), Penicillin (53.7%), Minocycline (46.3%), Ampicillin (44. %), Oxytetracycline (23.9%), Tetracycline(22.4 %), Doxycycline (20.9%), Streptomycin (22%), Kanamycin (16.4%), Gentamicin (7.4%), Cephalexin (1. 5%) and Cotrimoxazole (0%). 5. Frequency of resistant strain in K. pneumoniae isolated from residents of doctorless areas was the highest with Troleandomycin (100%) and Erythromycin (100%) followed by Carbenicillin (98.3%), Penicillin (44.8%), Minocycline (29.3%), Ampicillin (22.4%), Doxycycline (1. 7%), Cephal exin (1. 7%), Tetracycline (0%), Oxytetracycline (0%), Kanamycin (0%), Gentamicin (0%), Streptomycin (0%) and Cotrimoxazole (0%). There were significant differences in the incidence of resistant strains between two groups of K. pneumoniae with Ampicillin, Tetracycline, Oxytetracycline, Minecycline, Kanamycin, Gentamicin and Streptomycin (p<0.05). 6. In study with Ampicillin, Gentamicin, Kanamycin, Streptomycin. Tetracycline, Minocycline, Cephalexin, and Cotrirnoxasole, there were no multiple resistant strains in K. pneumoniae isolated from doctorless areas, while 23 strains of K. pneumoniae isolated from patients of Seoul National University Hospital showed multiple resistance. 7. There were high correlation in susceptibility of 125 strains of K. pneumoniae among Tetracycline, Oxytetracycline and Doxycycline (correlation coefficient O. 87~0. 94), but there were relatively low correlation in susceptibility between Minocycline and other 3 tetracvclines (Tetracycline, Oxytetracycline and Doxycycline). Correlation coefficient of susceptibility among penicillin analogues (Penicillin, Ampicillin and Carbenicillin) ranged between O. 30~0. 78. Correlation coefficient of susceptibility between Streptomycin and 3 tetracyclines (Tetracycline, Oxytetracycline and Doxycycline) ranged between O. 76~ 0.82. Correlation coefficient of susceptibility between Kanamycin and Streptomycin were 0.84.