심근 미토콘드리아의 소듐에 의한 칼슘유리가 액토마이오신 ATPase 활성도에 미치는 영향
Influence of Sodium-induced Calcium Release from. Cardiac Mitochondria on the Actomyosin ATPase Activity

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김명석; 김용식
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서울대학교 의과대학
Seoul J Med 1982;23(1):1-6
The calcium sensitive ATPase activity of actomy·
osin extracted from dog heart was measured in a
reaction condition, under which the release of calcium
from cardiac mitochondria could be induced by sodium.
In spite of sodium insensitivity, the ATPase
activity of actomyosin, when incubated with mitoch·
ondria, increased with the addition of 2~10mM sodium.
Such an increase in the activity of actomyosin
ATPasc was interpreted as the result of calcium
release from the mitochondria by sodium. And it was
also considered from the result that the sodium indo
uced calcium release from mitochondria might be
related with the positive inotropic effect of digitalis
cardiac glycoside, which could produce the elevation
of intracellular sodium secondary to the inhibition of
the mcml rane sodium-pump.
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 23 No.1 (1982)
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