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The Possible Role of Nitric Oxide on Enteric Nerves-Mediated Relaxation of the Gastric Smooth Muscle of the Guinea Pig
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ahn, Jung Mo | - |
dc.contributor.author | Ahn, Seung Cheol | - |
dc.contributor.author | Choi, Youn Baik | - |
dc.contributor.author | Kang, Tong Mook | - |
dc.contributor.author | Kim, Sung Joon | - |
dc.contributor.author | So, Insuk | - |
dc.contributor.author | Kim, Ki Whan | - |
dc.date.accessioned | 2009-08-20T05:29:08Z | - |
dc.date.available | 2009-08-20T05:29:08Z | - |
dc.date.issued | 1990-12 | - |
dc.identifier.citation | Seoul J Med, Vol.35 No.1, pp. 1-8 | - |
dc.identifier.issn | 0582-6802 | - |
dc.identifier.uri | https://hdl.handle.net/10371/7326 | - |
dc.description.abstract | The influence of the enteric nerves stimulation on the contractility of gastric
circular muscle was studied in guinea pig stomachs. The enteric nerves were activated by electric field stimulation(EFS; 90 V, 1 rns, 32 Hz square pulses for 1 s), EFS produced initial transient contraction followed by relaxation and slow recovery. The initial contraction was sensitively blocked by treatment with atropine. The following relaxation still occurred in nonadrenergic noncholinergidNANC) state. EFSinduced relaxation was reduced by LG-nitro-L-arginine(L-NNA), a nitric oxide(NO) synthase inhibitor. The relaxation was restored from the suppressed state after the application of L-arginine(L-arg), a substrate of nitric oxide synthase. With conventional intracellular recording, slow wave and inhibitory junction potential(IJP) were recorded. L-NNA had no effect on IJP, while apamin blocked it. In conclusion, it is suggested that NO may playa major role in EFS-induced relaxation. The exact mechanism of this relaxation is unknown, but the relaxation does not result from the IJP induced by the activation of apamin-sensitive potassium channels. | - |
dc.language.iso | en | - |
dc.publisher | Seoul National University College of Medicine | - |
dc.subject | EFS | - |
dc.subject | Lⁿ-Nitro-L-arginine | - |
dc.subject | Nitric oxide | - |
dc.subject | L-Arg | - |
dc.subject | Nonadrenergic noncholinergic | - |
dc.subject | Inhibitory junction potential | - |
dc.title | The Possible Role of Nitric Oxide on Enteric Nerves-Mediated Relaxation of the Gastric Smooth Muscle of the Guinea Pig | - |
dc.type | SNU Journal | - |
dc.contributor.AlternativeAuthor | 안중모 | - |
dc.contributor.AlternativeAuthor | 안승철 | - |
dc.contributor.AlternativeAuthor | 최윤백 | - |
dc.contributor.AlternativeAuthor | 강동묵 | - |
dc.contributor.AlternativeAuthor | 김성준 | - |
dc.contributor.AlternativeAuthor | 서인석 | - |
dc.contributor.AlternativeAuthor | 김기환 | - |
dc.citation.journaltitle | 서울 의대 잡지 | - |
dc.citation.journaltitle | 서울 의대 학술지 | - |
dc.citation.journaltitle | Seoul Journal of Medicine | - |
dc.citation.endpage | 8 | - |
dc.citation.number | 1 | - |
dc.citation.pages | 1-8 | - |
dc.citation.startpage | 1 | - |
dc.citation.volume | 35 | - |
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