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Generation of Cells With Hodgkin's and Reed-Sternberg Phenotype Through Downregulation of CD99 (Mic2)
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Soon Ha | - |
dc.contributor.author | Choi, Eun Young | - |
dc.contributor.author | Shin, Young Kee | - |
dc.contributor.author | Kim, Tae Jin | - |
dc.contributor.author | Chung, Doo Hyun | - |
dc.contributor.author | Chang, Sung Ik | - |
dc.contributor.author | Kim, Noe Kyeong | - |
dc.contributor.author | Park, Seong Hoe | - |
dc.date.accessioned | 2011-06-10T03:06:21Z | - |
dc.date.available | 2011-06-10T03:06:21Z | - |
dc.date.issued | 1998-12 | - |
dc.identifier.citation | Blood; Vol.92, No.11; pp.4287-4295 | en |
dc.identifier.issn | 1528-0020 | - |
dc.identifier.uri | https://hdl.handle.net/10371/73415 | - |
dc.description.abstract | Despite the fact that Hodgkins and Reed-Sternberg (H-RS) cells are morphological hallmarks of Hodgkins disease (HD), the nature of H-RS cells still remains to be resolved. Here we report that downregulation of CD99 (Mic2) leads to the generation of cells with an H-RS phenotype. IM9 and BJAB B-cell lines that were transfected with an antisense CD99 expression construct showed the morphological and immunological characteristics of H-RS cells such as multinuclearity, expression of CD15, decreased expression of major histocompatibility complex (MHC) class I and CD45RB, and deregulated secretion of cytokines. The reduced expression of CD99 was also confirmed in H-RS cells of patients lymph nodes and three HD-derived cell lines, L428, KM-H2, and HDLM-2. Moreover, features characteristic of H-RS cells were completely abolished by forced expression of CD99 and by a constitutively active form of Rac, which functions downstream of CD99. We suggest that CD99 molecules play a crucial role in regulating functions and morphology of cells through a Rac-Rho signaling pathway and that the loss of CD99 expression is a significant molecular event to generate H-RS cells. | en |
dc.description.sponsorship | Supported by a grant (HMP-96-M-2-1073) of the 96 Good Health R&D Project, Ministry of Health & Welfare, Republic of Korea. | en |
dc.language.iso | en | en |
dc.publisher | American Society of Hematology | en |
dc.title | Generation of Cells With Hodgkin's and Reed-Sternberg Phenotype Through Downregulation of CD99 (Mic2) | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김순하 | - |
dc.contributor.AlternativeAuthor | 최은영 | - |
dc.contributor.AlternativeAuthor | 신영기 | - |
dc.contributor.AlternativeAuthor | 김태진 | - |
dc.contributor.AlternativeAuthor | 정두현 | - |
dc.contributor.AlternativeAuthor | 장성익 | - |
dc.contributor.AlternativeAuthor | 김노경 | - |
dc.contributor.AlternativeAuthor | 박성회 | - |
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