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Overexpression of Interleukin-10 in Sentinel Lymph Node with Breast Cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Woo, Sang Uk | - |
dc.contributor.author | Bae, Jeoung Won | - |
dc.contributor.author | Yang, Jung-Hyun | - |
dc.contributor.author | Kim, Jung Han | - |
dc.contributor.author | Nam, Seok Jin | - |
dc.contributor.author | Shin, Young Kee | - |
dc.date.accessioned | 2011-06-13T06:19:04Z | - |
dc.date.available | 2011-06-13T06:19:04Z | - |
dc.date.issued | 2007-11 | - |
dc.identifier.citation | Ann. Surg. Oncol.; Vol.14(11); pp.3268–3273 | en |
dc.identifier.issn | 1068-9265 | - |
dc.identifier.uri | https://hdl.handle.net/10371/73423 | - |
dc.description.abstract | Background: In breast carcinoma, identification of tumor cells in the sentinel lymph nodes is a predictor of the tumors metastatic potential. Sentinel lymph node may be targeted not only by tumor cell metastasis but also by cytokines from the emergence of antitumor immune responses.
Methods: Between February 2003 and February 2004, the investigator evaluated 38 cases that underwent sentinel lymph node biopsy at the Samsung Medical Center. Eighty paraffin-embedded sections, 49 sentinel, and 31 nonsentinel lymph node, from breast carcinoma without lymphatic metastases were analyzed by real-time polymerase chain reaction to evaluate the cytokine profile (interferon-γ, interleukin-2, interleukin-10 and interleukin-12) for the T cell response. Results: A higher expression of interleukin-10 was observed in sentinel lymph node than in nonsentinel lymph node (P = 0.03). The expressions of interferon-γ, interleukin-2, and interleukin-12 were similar between sentinel and nonsentinel lymph node. Conclusions: Theses results indicate that T cell response was downregulated by interleukin-10 overexpression in sentinel lymph node with breast cancer. | en |
dc.language.iso | en | en |
dc.publisher | Springer Verlag | en |
dc.subject | Breast carcinoma | en |
dc.subject | Sentinel lymph node | en |
dc.subject | Cytokine | en |
dc.subject | Interleukin-10 | en |
dc.subject | Real-time quantitative polymerase chain reaction | en |
dc.title | Overexpression of Interleukin-10 in Sentinel Lymph Node with Breast Cancer | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 우상욱 | - |
dc.contributor.AlternativeAuthor | 배정원 | - |
dc.contributor.AlternativeAuthor | 양정현 | - |
dc.contributor.AlternativeAuthor | 김정한 | - |
dc.contributor.AlternativeAuthor | 남석진 | - |
dc.contributor.AlternativeAuthor | 신영기 | - |
dc.identifier.doi | 10.1245/s10434-007-9532-3 | - |
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