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Induction of a Neuronal Phenotype from Human Bone Marrow-Derived Mesenchymal Stem Cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Oh, Soonyi | - |
dc.contributor.author | Park, Hwan-Woo | - |
dc.contributor.author | Cho, Jung-Sun | - |
dc.contributor.author | Jung, Heekyung | - |
dc.contributor.author | Lee, Seung-Pyo | - |
dc.contributor.author | Paik, Ki-Suk | - |
dc.contributor.author | Chang, Mi-Sook | - |
dc.date.accessioned | 2011-08-29T04:47:31Z | - |
dc.date.available | 2011-08-29T04:47:31Z | - |
dc.date.issued | 2009-12-31 | - |
dc.identifier.citation | International Journal of Oral Biology Vol.34 No.4, pp. 177-183 | en |
dc.identifier.issn | 1226-7155 | - |
dc.identifier.uri | https://hdl.handle.net/10371/73525 | - |
dc.description.abstract | Human mesenchymal stem cell (hMSCs) isolated from human adult bone marrow have self-renewal capacity and can differentiate into multiple cell types in vitro and in vivo. A number of studies have now demonstrated that MSCs can differentiate into various neuronal populations. Due to their autologous characteristics, replacement therapy using MSCs is considered to be safe and does not involve immunological complications. The basic helix-loop-helix (bHLH) transcription factor Olig2 is necessary for the specification of both oligodendrocytes and motor neurons during vertebrate embryogenesis. To develop an efficient method for inducing neuronal differentiation from MSCs, we attempted to optimize the culture conditions and combination with Olig2 gene overexpression. We observed neuron-like morphological changes in the hMSCs under these induction conditions and examined neuronal marker expression in these cells by RTPCR and immunocytochemistry. Our data demonstrate that the combination of Olig2 overexpression and neuron-specific conditioned medium facilitates the neuronal differentiation of hMSCs in vitro. These results will advance the development of an efficient stem cell-mediated cell therapy for human neurodegenerative diseases. | en |
dc.description.sponsorship | This research was supported by a grant from the NationalResearch Foundation of Korea (M-SC, 2006-KRF-531-C00043). | - |
dc.language.iso | en | - |
dc.publisher | The Korean Academy of Oral Biology | en |
dc.subject | mesenchymal stem cells | en |
dc.subject | transcription factor | en |
dc.subject | neuron | en |
dc.subject | differentiation | en |
dc.subject | induction | en |
dc.title | Induction of a Neuronal Phenotype from Human Bone Marrow-Derived Mesenchymal Stem Cells | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 오순이 | - |
dc.contributor.AlternativeAuthor | 박환우 | - |
dc.contributor.AlternativeAuthor | 조정선 | - |
dc.contributor.AlternativeAuthor | 정희경 | - |
dc.contributor.AlternativeAuthor | 이승표 | - |
dc.contributor.AlternativeAuthor | 백기석 | - |
dc.contributor.AlternativeAuthor | 장미숙 | - |
dc.citation.journaltitle | International Journal of Oral Biology | - |
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