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Loss of hsp70.1 decreases functional motor recovery after spinal cord injury in mice

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dc.contributor.authorKim, Hyun Jeong-
dc.contributor.authorJung, Ji-In-
dc.contributor.authorKim, Youngkyung-
dc.contributor.authorLee, Jae-Seon-
dc.contributor.authorYoon, Young Wook-
dc.contributor.authorKim, Junesun-
dc.date.accessioned2011-10-14-
dc.date.available2011-10-14-
dc.date.issued2010-06-
dc.identifier.citationKorean J Physiol Pharmacol 2010;14:157-161en
dc.identifier.issn1226-4512-
dc.identifier.urihttp://hdl.handle.net/10371/74126-
dc.description.abstractHeat shock proteins (HSPs) are specifically induced by various forms of stress. Hsp70.1, a member of the hsp70 family is known to play an important role in cytoprotection from stressful insults. However, the functional role of Hsp70 in motor function after spinal cord injury (SCI) is still unclear. To study the role of hsp70.1 in motor recovery following SCI, we assessed locomotor function in hsp70.1 knockout (KO) mice and their wild-type (WT) mice via the Basso, Beattie and Bresnahan (BBB) locomotor rating scale, before and after spinal hemisection at T13 level. We also examined lesion size in the spinal cord using Luxol fast blue/cresyl violet staining. One day after injury, KO and WT mice showed no significant difference in the motor function due to complete paralysis following spinal hemisection. However, when it compared to WT mice, KO mice had significantly delayed and decreased functional outcomes from 4 days up to 21 days after SCI. KO mice also showed significantly greater lesion size in the spinal cord than WT mice showed at 21 days after spinal hemisection. These results suggest that Hsp70 has a protective effect against traumatic SCI and the manipulation of the hsp70.1 gene may help improve the recovery of motor function, thereby enhancing neuroprotection after SCI.en
dc.description.sponsorshipThis work was supported by a grant of the Korea University College of Health Science(K1031191).en
dc.language.isoen-
dc.publisherThe Korean Physiological Society & the Koreanen
dc.subjectSpinal cord injuryen
dc.subjectNeuroprotectionen
dc.subjectHeat shock proteinen
dc.subjectMiceen
dc.titleLoss of hsp70.1 decreases functional motor recovery after spinal cord injury in miceen
dc.typeArticleen
dc.contributor.AlternativeAuthor김현정-
dc.contributor.AlternativeAuthor정지인-
dc.contributor.AlternativeAuthor김영경-
dc.contributor.AlternativeAuthor이재선-
dc.contributor.AlternativeAuthor윤영욱-
dc.contributor.AlternativeAuthor김준선-
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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