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Effects of poly(lactic-co-glycolic acid) (PLGA) degradability on the apatite-forming capacity of electrospun PLGA/SiO2-CaO nonwoven composite fabrics
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, In Ae | - |
dc.contributor.author | Rhee, Sang-Hoon | - |
dc.date.accessioned | 2011-10-14 | - |
dc.date.available | 2011-10-14 | - |
dc.date.issued | 2010-04 | - |
dc.identifier.citation | Journal of Biomedical Materials Research - Part B Applied Biomaterials 2010;93:218-226 | en |
dc.identifier.issn | 1552-4973 | - |
dc.identifier.uri | https://hdl.handle.net/10371/74129 | - |
dc.description.abstract | We investigated the effects of poly(lactic-co-glycolic acid) (PLGA) degradability on the apatite-forming ability of electrospun PLGA/SiO 2-CaO gel composite fabric. Two PLGA copolymer compositions with low and high degradability were used in experiments. A nonwoven polymer/ceramic composite fabric composed of randomly mixed microsized biodegradable PLGA fibers and nanosized bioactive SiO2-CaO gel fibers was prepared using a simultaneous electrospinning method. A 17 wt.% PLGA solution was prepared using 1,1,3,3-hexafluoro-2-propanol as a solvent, while the SiO2-CaO gel solution was prepared via a condensation reaction following hydrolysis of tetraethyl orthosilicate under acidic conditions. PLGA and SiO2-CaO gel solutions were spun simultaneously with two separate nozzles under electric fields of 1 and 2 kV/cm using two syringe pumps with flow rates of 7.5 and 5 mL/h, respectively. As controls, low and high degradable PLGA and SiO 2-CaO gel nonwoven fabrics were also made by the same methods. The five nonwoven fabrics that were produced were exposed to simulated body fluid (SBF) for 1 week. SBF exposure resulted in the deposition of a layer of apatite crystals on the surfaces of both the SiO2-CaO gel and the low degradable PLGA/SiO2-CaO gel composite fabrics, but not on the low and high degradable PLGA or the high degradable PLGA/SiO2-CaO gel composite fabrics. The results are explained in terms of the acidity of the PLGA degradation products, which could have a direct influence on apatite dissolution. | en |
dc.description.sponsorship | Contract grant sponsor: Korea Science and Engineering Foundation; contract grant numbers: R01-2005-000-10375-0, M0528010001-06N2801-00110 (Nano Bio R&D Program) | en |
dc.language.iso | en | en |
dc.publisher | Wiley-Blackwell | en |
dc.subject | Bioactivity | en |
dc.subject | Degradability | en |
dc.subject | Electrospinning | en |
dc.subject | PLGA | en |
dc.subject | SiO2-CaO | en |
dc.title | Effects of poly(lactic-co-glycolic acid) (PLGA) degradability on the apatite-forming capacity of electrospun PLGA/SiO2-CaO nonwoven composite fabrics | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김인애 | - |
dc.contributor.AlternativeAuthor | 이상훈 | - |
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