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The effect of a laminin-5-derived peptide coated onto chitin microfibers on re-epithelialization in early-stage wound healing
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Min, Seung-Ki | - |
dc.contributor.author | Lee, Sang-Chul | - |
dc.contributor.author | Hong, Seong-Doo | - |
dc.contributor.author | Park, Won Ho | - |
dc.contributor.author | Min, Byung-Moo | - |
dc.date.accessioned | 2011-10-14T06:15:16Z | - |
dc.date.available | 2011-10-14T06:15:16Z | - |
dc.date.issued | 2010-06 | - |
dc.identifier.citation | Biomaterials 2010;31:4725-30 | en |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.uri | https://hdl.handle.net/10371/74158 | - |
dc.description.abstract | Considerable effort has been directed towards regenerating defective tissues using tissue-engineering methods. Recently, peptides have been recognized as a valuable scientific tool in the field of tissue-engineering. The PPFLMLLKGSTR motif of the human laminin-5 α3 chain has been previously reported to promote keratinocyte survival; however, the in vivo effects of the PPFLMLLKGSTR motif have not yet been studied. These studies raised the hypothesis that a laminin-5-derived peptide can promote wound healing by accelerating re-epithelialization in vivo. To examine this hypothesis, we applied chitin microfibrous matrices coated with the PPFLMLLKGSTR motif in both rat and rabbit full-thickness cutaneous wound models. Compared with vehicle-treated and peptide-treated cutaneous wounds, the application significantly promoted early-stage wound healing by accelerating re-epithelialization, notably reduced inflammatory cell infiltration, and prominently enhanced fibroblast proliferation. These findings support our hypothesis that the PPFLMLLKGSTR motif acts as a very effective wound healing accelerator by enhancing re-epithelialization. | en |
dc.description.sponsorship | This study was supported by a grant of the Korea Healthcare Technology R&D Project, Ministry for Health, Welfare & Family Affairs, Republic of Korea (A090648). | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Laminin-5-derived peptide | en |
dc.subject | Wound dressing material | en |
dc.subject | Tissue-engineering | en |
dc.subject | Re-epithelialization | en |
dc.subject | Wound healing | en |
dc.title | The effect of a laminin-5-derived peptide coated onto chitin microfibers on re-epithelialization in early-stage wound healing | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 민승기 | - |
dc.contributor.AlternativeAuthor | 이상철 | - |
dc.contributor.AlternativeAuthor | 홍성두 | - |
dc.contributor.AlternativeAuthor | 박원호 | - |
dc.contributor.AlternativeAuthor | 민병무 | - |
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