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Electrospun silk fibroin scaffolds with macropores for bone regeneration: An in vitro and in vivo study

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dc.contributor.authorPark, Sook Young-
dc.contributor.authorKi, Chang Seok-
dc.contributor.authorPark, Young Hwan-
dc.contributor.authorJung, Hong Moon-
dc.contributor.authorWoo, Kyung Mi-
dc.contributor.authorKim, Hyun Jeong-
dc.date.accessioned2011-10-14T08:21:54Z-
dc.date.available2011-10-14T08:21:54Z-
dc.date.issued2010-04-
dc.identifier.citationTissue Engineering - Part A 16:4,1271-1279en
dc.identifier.issn1937-3341-
dc.identifier.urihttp://hdl.handle.net/10371/74174-
dc.description.abstractWe developed three-dimensional electrospun silk fibroin (ESF) scaffolds with controllable pore size. The purpose of this study was to evaluate ESF scaffolds with pores (P-ESF) for bone regeneration via in vitro and in vivo studies, with a comparison to a commercially available porous three-dimensional polylactic acid (PLA) scaffold. P-ESF supported significantly higher proliferation and alkaline phosphatase activity of osteoblasts than PLA in vitro (p<0.05). Moreover, higher expression levels of activated adhesion-related proteins, including focal adhesion kinase, were observed in the P-ESF than in PLA, as confirmed by western blot analyses. Microcomputed tomography revealed that 78.30% of the original bone volume was attained in the P-ESF implantation group at 7 weeks after critical bone defect formation in rat calvaria. Comparatively, the PLA implantation group showed only 49.31%. Histological evaluation also showed new bone tissue formation upon P-ESF implantation. Taken together, the P-ESF scaffold may be a good bone substitute for bone regeneration.en
dc.description.sponsorshipThe authors thank the Korea Science and Engineering Foundation (KOSEF) and Rural Development Administration, Republic of Korea, for sponsoring this research through
the SRC=ERC Program of MOST=KOSEF (R11-2005-065), and BioGreen21 Program (200810FTH010102001).
en
dc.language.isoenen
dc.publisherMary Ann Lieberten
dc.titleElectrospun silk fibroin scaffolds with macropores for bone regeneration: An in vitro and in vivo studyen
dc.typeArticleen
dc.contributor.AlternativeAuthor박숙영-
dc.contributor.AlternativeAuthor기창석-
dc.contributor.AlternativeAuthor박영환-
dc.contributor.AlternativeAuthor정홍문-
dc.contributor.AlternativeAuthor우경미-
dc.contributor.AlternativeAuthor김현정-
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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