Publications
Detailed Information
Biomimetic nanofibrous scaffolds: Preparation and characterization of chitin/silk fibroin blend nanofibers
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Ko Eun | - |
dc.contributor.author | Jung, Sung Youn | - |
dc.contributor.author | Lee, Seung Jin | - |
dc.contributor.author | Min, Byung-Moo | - |
dc.contributor.author | Park, Won Ho | - |
dc.date.accessioned | 2011-10-20 | - |
dc.date.available | 2011-10-20 | - |
dc.date.issued | 2006-05 | - |
dc.identifier.citation | Int. J. Biol. Macromol., 38(2006)165 | en |
dc.identifier.issn | 0141-8130 | - |
dc.identifier.uri | https://hdl.handle.net/10371/74359 | - |
dc.description.abstract | Electrospinning of chitin/silk fibroin (SF) blend solutions in 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) was investigated to fabricate a biomimetic nanostructured scaffolds for tissue engineering. The morphology of the electrospun chitin/SF blend nanofibers was investigated with a field emission scanning electron microscope (FE-SEM). The average diameters of chitin/SF blend fibers decreased from 920 to 340 nm, with the increase of chitin content in blend compositions. The miscibility of chitin/SF blend fibers was examined by solution viscosity measurement. The chitin and SF were immiscible in the as-spun nanofibrous structure. The dimensional stability of chitin/SF blend nanofibers, with or without water vapor after-treatment, was conducted by immersing in water. As-spun SF-rich blend nanofibrous matrices were lost their fibrous structure after the water immersion for 24 h, and then changed into membrane-like structure. On the contrary, nanofibrous structures of water vapor-treated SF-rich blends were almost maintained. To assay the cytocompatibility and cell behavior on the chitin/SF blend nanofibrous scaffolds, cell attachment and spreading of normal human epidermal keratinocyte and fibroblasts seeded on the scaffolds were studied. Our results indicate that chitin/SF blend nanofibrous matrix, particularly the one that contained 75% chitin and 25% SF, could be a potential candidate for tissue engineering scaffolds because it has both biomimetic three-dimensional structure and an excellent cell attachment and spreading for NHEK and NHEF. | en |
dc.description.sponsorship | This work was supported by a grant from the Korean Ministry of Commerce, Industry, and Energy and by a grant from the Korean Science and Engineering Foundation through the Intellectual Biointerface Engineering Center at Seoul National University. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Electrospinning | en |
dc.subject | Chitin | en |
dc.subject | Silk fibroin | en |
dc.subject | Blend nanofiber | en |
dc.subject | Matrix | en |
dc.subject | Fibroblast | en |
dc.title | Biomimetic nanofibrous scaffolds: Preparation and characterization of chitin/silk fibroin blend nanofibers | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 박고은 | - |
dc.contributor.AlternativeAuthor | 정성윤 | - |
dc.contributor.AlternativeAuthor | 이승진 | - |
dc.contributor.AlternativeAuthor | 민병무 | - |
dc.contributor.AlternativeAuthor | 박원호 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.