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Early recombinant human epidermal growth factor treatment recovers the irradiation-induced decrease of Na plus absorption prior to the definite histological mucositis

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dc.contributor.authorKim, Jin Kyoung-
dc.contributor.authorKim, Chung Su-
dc.contributor.authorAhn, Hyun Joo-
dc.contributor.authorYoo, Hae Young-
dc.contributor.authorJeong, Han-Sin-
dc.contributor.authorKim, Sung Joon-
dc.contributor.authorBang, Si Ra-
dc.date.accessioned2012-05-22T02:37:56Z-
dc.date.available2012-05-22T02:37:56Z-
dc.date.issued2010-11-
dc.identifier.citationBIOMEDICINE & PHARMACOTHERAPY; Vol.64 9; 594-599ko_KR
dc.identifier.issn0753-3322-
dc.identifier.urihttp://hdl.handle.net/10371/76210-
dc.description.abstractRecombinant human epidermal growth factor (rhEGF) has potential benefit for the mucositis induced by radiation therapy as a therapeutic setting. In this study, we aimed to investigate the effects of rhEGF treatment on the radiation-induced changes in epithelial transport function, before the occurrence of the definitive histological mucosal changes. C3H/He mice received 0, 4, or 8 Gy irradiation and/or EGF treatment (rhEGF 0, 1 and 5 mg/kg, i.p., 5 days). At day 7, we recorded short circuit current (I(sc)) of the upper tracheal epithelium using the flow-type Ussing chamber method, with histological analysis. As a result, there was no evident pathological change in the epithelium from the irradiated and/or rhEGF treated mice at day 7. The initial level of I(sc) and amiloride-sensitive I(sc) (Delta I(sc,Amil)) were decreased after 8 Gy irradiation, reflecting suppression of basal Na(+) absorption. The decreased 6,1,Amil was recovered by rhEGF treatment. In conclusion, epithelial Na(+) channel-dependent basal Na(+) absorption was primarily affected by irradiation, before the pathological changes. The recovery of basal Na(+) absorption (Delta I(sc,Amil)) suggested a potentially beneficial effect of early rhEGF treatment for irradiation-induced suppression of the upper aerodigestive epithelial functions. (C) 2010 Elsevier Masson SAS. All rights reserved.ko_KR
dc.language.isoenko_KR
dc.publisherELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIERko_KR
dc.subjectRadiationko_KR
dc.subjectEpidermal growth factorko_KR
dc.subjectIon transportko_KR
dc.subjectShort circuit currentko_KR
dc.subjectEpitheliumko_KR
dc.titleEarly recombinant human epidermal growth factor treatment recovers the irradiation-induced decrease of Na plus absorption prior to the definite histological mucositisko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor김진경-
dc.contributor.AlternativeAuthor김청수-
dc.contributor.AlternativeAuthor안현주-
dc.contributor.AlternativeAuthor김성준-
dc.contributor.AlternativeAuthor정한신-
dc.contributor.AlternativeAuthor유해영-
dc.contributor.AlternativeAuthor방시라-
dc.identifier.doi10.1016/j.biopha.2010.06.005-
dc.citation.journaltitleBIOMEDICINE & PHARMACOTHERAPY-
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dc.description.tc0-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Physiology (생리학교실)Journal Papers (저널논문_생리학교실)
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