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Early recombinant human epidermal growth factor treatment recovers the irradiation-induced decrease of Na plus absorption prior to the definite histological mucositis
DC Field | Value | Language |
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dc.contributor.author | Kim, Jin Kyoung | - |
dc.contributor.author | Kim, Chung Su | - |
dc.contributor.author | Ahn, Hyun Joo | - |
dc.contributor.author | Yoo, Hae Young | - |
dc.contributor.author | Jeong, Han-Sin | - |
dc.contributor.author | Kim, Sung Joon | - |
dc.contributor.author | Bang, Si Ra | - |
dc.date.accessioned | 2012-05-22T02:37:56Z | - |
dc.date.available | 2012-05-22T02:37:56Z | - |
dc.date.issued | 2010-11 | - |
dc.identifier.citation | BIOMEDICINE & PHARMACOTHERAPY; Vol.64 9; 594-599 | ko_KR |
dc.identifier.issn | 0753-3322 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76210 | - |
dc.description.abstract | Recombinant human epidermal growth factor (rhEGF) has potential benefit for the mucositis induced by radiation therapy as a therapeutic setting. In this study, we aimed to investigate the effects of rhEGF treatment on the radiation-induced changes in epithelial transport function, before the occurrence of the definitive histological mucosal changes. C3H/He mice received 0, 4, or 8 Gy irradiation and/or EGF treatment (rhEGF 0, 1 and 5 mg/kg, i.p., 5 days). At day 7, we recorded short circuit current (I(sc)) of the upper tracheal epithelium using the flow-type Ussing chamber method, with histological analysis. As a result, there was no evident pathological change in the epithelium from the irradiated and/or rhEGF treated mice at day 7. The initial level of I(sc) and amiloride-sensitive I(sc) (Delta I(sc,Amil)) were decreased after 8 Gy irradiation, reflecting suppression of basal Na(+) absorption. The decreased 6,1,Amil was recovered by rhEGF treatment. In conclusion, epithelial Na(+) channel-dependent basal Na(+) absorption was primarily affected by irradiation, before the pathological changes. The recovery of basal Na(+) absorption (Delta I(sc,Amil)) suggested a potentially beneficial effect of early rhEGF treatment for irradiation-induced suppression of the upper aerodigestive epithelial functions. (C) 2010 Elsevier Masson SAS. All rights reserved. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER | ko_KR |
dc.subject | Radiation | ko_KR |
dc.subject | Epidermal growth factor | ko_KR |
dc.subject | Ion transport | ko_KR |
dc.subject | Short circuit current | ko_KR |
dc.subject | Epithelium | ko_KR |
dc.title | Early recombinant human epidermal growth factor treatment recovers the irradiation-induced decrease of Na plus absorption prior to the definite histological mucositis | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김진경 | - |
dc.contributor.AlternativeAuthor | 김청수 | - |
dc.contributor.AlternativeAuthor | 안현주 | - |
dc.contributor.AlternativeAuthor | 김성준 | - |
dc.contributor.AlternativeAuthor | 정한신 | - |
dc.contributor.AlternativeAuthor | 유해영 | - |
dc.contributor.AlternativeAuthor | 방시라 | - |
dc.identifier.doi | 10.1016/j.biopha.2010.06.005 | - |
dc.citation.journaltitle | BIOMEDICINE & PHARMACOTHERAPY | - |
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dc.description.tc | 0 | - |
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