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Differential alternative splicing of human transglutaminase 4 in benign prostate hyperplasia and prostate cancer
DC Field | Value | Language |
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dc.contributor.author | Cho, Sung-Yup | - |
dc.contributor.author | Choi, Kyungho | - |
dc.contributor.author | Kim, Chai-Wan | - |
dc.contributor.author | Jeon, Ju-Hong | - |
dc.contributor.author | Lee, Jong Bouk | - |
dc.contributor.author | Kim, Choung-Soo | - |
dc.contributor.author | Jeong, Eui Man | - |
dc.contributor.author | Song, Kye-Yong | - |
dc.contributor.author | Kim, In-Gyu | - |
dc.contributor.author | Jang, Gi-Yong | - |
dc.contributor.author | Park, Jeong-Soo | - |
dc.contributor.author | Lee, Sang Eun | - |
dc.contributor.author | Shin, Dong-Myung | - |
dc.date.accessioned | 2012-05-22T05:10:50Z | - |
dc.date.available | 2012-05-22T05:10:50Z | - |
dc.date.issued | 2010-04-30 | - |
dc.identifier.citation | EXPERIMENTAL AND MOLECULAR MEDICINE; Vol.42 4; 310-318 | ko_KR |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76226 | - |
dc.description.abstract | Transglutaminase 4 is a member of enzyme family that catalyzes calcium-dependent posttranslational modification of proteins. Although transglutaminase 4 has been shown to have prostate-restricted expression pattern, little is known about the biological function of transglutaminase 4 in human. To gain insight into its role in prostate, we analyzed the expression status of human transglutaminase 4 in benign prostate hyperplasia (BPH) and prostate cancer (PCa). Unexpectedly, RT-PCR and nucleotide sequence analysis showed four alternative splicing variants of transglutaminase 4: transglutaminase 4-L, -M (-M1 and -M2) and -S. The difference between transglutaminase 4-M1 and -M2 is attributed to splicing sites, but not nucleotide size. The deduced amino acid sequences showed that transglutaminase 4-L, -M1 and -M2 have correct open reading frames, whereas transglutaminase 4-S has a truncated reading frame. RT-PCR analysis of clinical samples revealed that transglutaminase 4-M and -S were detected in all tested prostate tissue (80 BPH and 48 PCa). Interestingly, transglutaminase 4-L was found in 56% of BPH (45 out of 80) and only in 15% of PCa (7 out of 48). However, transglutaminase 4-L expression did not correlate with serum prostate-specific antigen (PSA) level, prostate volumes or PSA densities. These results will provide a clue to future investigation aiming at delineating physiological and pathological roles of human transglutaminase 4. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | KOREAN SOC MED BIOCHEMISTRY MOLECULAR BIOLOGY | ko_KR |
dc.subject | alternative splicing | ko_KR |
dc.subject | prostate hyperplasia | ko_KR |
dc.subject | prostatic neoplasms | ko_KR |
dc.subject | transglutaminase 4 | ko_KR |
dc.title | Differential alternative splicing of human transglutaminase 4 in benign prostate hyperplasia and prostate cancer | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 조성엽 | - |
dc.contributor.AlternativeAuthor | 김채완 | - |
dc.contributor.AlternativeAuthor | 최경호 | - |
dc.contributor.AlternativeAuthor | 전주홍 | - |
dc.contributor.AlternativeAuthor | 신동명 | - |
dc.contributor.AlternativeAuthor | 이상은 | - |
dc.contributor.AlternativeAuthor | 김인규 | - |
dc.contributor.AlternativeAuthor | 송계용 | - |
dc.contributor.AlternativeAuthor | 장기용 | - |
dc.contributor.AlternativeAuthor | 정의만 | - |
dc.contributor.AlternativeAuthor | 박정수 | - |
dc.contributor.AlternativeAuthor | 김청수 | - |
dc.contributor.AlternativeAuthor | 이종복 | - |
dc.identifier.doi | 10.3858/emm.2010.42.4.031 | - |
dc.citation.journaltitle | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
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dc.description.tc | 0 | - |
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