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Tacrolimus Concentrations in Relation to CYP3A and ABCB1 Polymorphisms Among Solid Organ Transplant Recipients in Korea
DC Field | Value | Language |
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dc.contributor.author | Jun, Kyung Ran | - |
dc.contributor.author | Lee, Woochang | - |
dc.contributor.author | Jang, Mi Sook | - |
dc.contributor.author | Chun, Sail | - |
dc.contributor.author | Park, Kwan Tae | - |
dc.contributor.author | Han, Duck Jong | - |
dc.contributor.author | Cho, Dae-Yeon | - |
dc.contributor.author | Min, Won-Ki | - |
dc.contributor.author | Kim, Jin Q. | - |
dc.contributor.author | Kang, Changwon | - |
dc.contributor.author | Lee, Sung Gyu | - |
dc.contributor.author | Song, Gi-Won | - |
dc.date.accessioned | 2012-05-22T06:10:19Z | - |
dc.date.available | 2012-05-22T06:10:19Z | - |
dc.date.issued | 2009-04-27 | - |
dc.identifier.citation | TRANSPLANTATION; Vol.87 8; 1225-1231 | ko_KR |
dc.identifier.issn | 0041-1337 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76235 | - |
dc.description.abstract | Background. Cytochrome P450 3A (CYP3A) and the drug transporter P-glycoprotein (P-gp) affect the bioavailability of tacrolimus, the most commonly used immunosuppressive agent in organ transplant recipients. We have determined the genotypic frequencies of the CYP3A and ATP-binding cassette sub-family B member 1 (ABCB1) genes, which encode the CYP3A and P-gp proteins, respectively, in Korean organ transplant recipients and donors, and have assessed the influence of CYP3A and ABCB1 polymorphisms on tacrolimus concentrations. Methods. Using chip-based MALDI-TOF mass spectrometry, 506 solid organ transplant recipients and 62 corresponding of liver transplant donors were genotyped for CYP3A4*6, CYP3A4*18, CYP3A5*3, CYP3A5P1*3, ABCB1 c.2677G>A/T, and ABCB1 c.3435C>T alleles, and their steady-state blood concentrations of tacrolimus were measured. Results. Frequencies of variant alleles among the transplant recipients were CYP3A5*3 76.8%, CYP3A5P1*3 75.9%, ABCB1 c.2677A/T 52.8%, ABCB1 c.3435T 36.9%, CYP3A4*18 1.9%, and CYP3A4*60.3%. The CYP3A5P1*3 allele was strongly linked to the CYP3A5*3 allele (r(2)=0.816). Patients with the CYP3A5*3 and CYP3A5P1*3 alleles showed higher blood tacrolimus concentrations per adjusted dose ratio than did patients with wild-type alleles, among both liver transplant donors and renal transplant recipients. Conclusion. The CYP3A5 genotype of the liver is considered to show the most important association with tacrolimus concentrations. Ultimately, genotyping for CYP3A5 may help optimal individualization of immunosuppressive drug therapy for patients undergoing solid organ transplantation. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | ko_KR |
dc.subject | Tacrolimus | ko_KR |
dc.subject | CYP3A | ko_KR |
dc.subject | Polymorphism | ko_KR |
dc.subject | ABCB1 | ko_KR |
dc.title | Tacrolimus Concentrations in Relation to CYP3A and ABCB1 Polymorphisms Among Solid Organ Transplant Recipients in Korea | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 전경란 | - |
dc.contributor.AlternativeAuthor | 이우창 | - |
dc.contributor.AlternativeAuthor | 장미숙 | - |
dc.contributor.AlternativeAuthor | 전사일 | - |
dc.contributor.AlternativeAuthor | 송기원 | - |
dc.contributor.AlternativeAuthor | 박관태 | - |
dc.contributor.AlternativeAuthor | 이성규 | - |
dc.contributor.AlternativeAuthor | 한덕종 | - |
dc.contributor.AlternativeAuthor | 강창원 | - |
dc.contributor.AlternativeAuthor | 조대연 | - |
dc.contributor.AlternativeAuthor | 김진규 | - |
dc.contributor.AlternativeAuthor | 민원기 | - |
dc.identifier.doi | 10.1097/TP.0b013e31819f117e | - |
dc.citation.journaltitle | TRANSPLANTATION | - |
dc.description.citedreference | Choi JH, 2007, BRIT J CLIN PHARMACO, V64, P185, DOI 10.1111/j.1365-2125.2007.02874.x | - |
dc.description.citedreference | Masuda S, 2006, PHARMACOL THERAPEUT, V112, P184, DOI 10.1016/j.pharmthera.2006.04.006 | - |
dc.description.citedreference | Fukudo M, 2006, CLIN PHARMACOL THER, V80, P331, DOI 10.1016/j.clpt.2006.06.008 | - |
dc.description.citedreference | Yu SF, 2006, TRANSPLANTATION, V81, P46, DOI 10.1097/01.tp.00000188118.34633.bf | - |
dc.description.citedreference | YU SF, 2006, HEPATOB PANCREAT DIS, V5, P337 | - |
dc.description.citedreference | Mourad M, 2005, TRANSPLANTATION, V80, P977, DOI 10.1097/01.TP.0000174131.47469.D2 | - |
dc.description.citedreference | Zhang X, 2005, CLIN TRANSPLANT, V19, P638, DOI 10.1111/j.1399-0012.2005.00370.x | - |
dc.description.citedreference | Rodriguez-Antona C, 2005, J BIOL CHEM, V280, P28324, DOI 10.1074/jbc.M502309200 | - |
dc.description.citedreference | Xin XJ, 2005, NEUROSCI LETT, V381, P284 | - |
dc.description.citedreference | Tada H, 2005, TRANSPLANT P, V37, P1730, DOI 10.1016/j.transproceed.2005.02.073 | - |
dc.description.citedreference | Zhao Y, 2005, TRANSPLANT P, V37, P178, DOI 10.1016/j.transproceed.2005.01.077 | - |
dc.description.citedreference | First MR, 2004, J NEPHROL, V17, pS25 | - |
dc.description.citedreference | Staatz CE, 2004, CLIN PHARMACOKINET, V43, P623 | - |
dc.description.citedreference | SAEKI M, 2003, HUM MUTAT, V21, P653 | - |
dc.description.citedreference | Macphee IAM, 2002, TRANSPLANTATION, V74, P1486, DOI 10.1097/01.TP.0000045761.71385.9F | - |
dc.description.citedreference | Goh BC, 2002, J CLIN ONCOL, V20, P3683, DOI 10.1200/JCO.2002.01.025 | - |
dc.description.citedreference | Kim RB, 2002, PHARMACOGENETICS, V12, P425 | - |
dc.description.citedreference | Goto M, 2002, PHARMACOGENETICS, V12, P451 | - |
dc.description.citedreference | Zhu B, 2002, ACTA PHARMACOL SIN, V23, P567 | - |
dc.description.citedreference | Hustert E, 2001, PHARMACOGENETICS, V11, P773 | - |
dc.description.citedreference | Dai D, 2001, J PHARMACOL EXP THER, V299, P825 | - |
dc.description.citedreference | Kuehl P, 2001, NAT GENET, V27, P383 | - |
dc.description.citedreference | Hsieh KP, 2001, DRUG METAB DISPOS, V29, P268 | - |
dc.description.citedreference | Hoffmeyer S, 2000, P NATL ACAD SCI USA, V97, P3473 | - |
dc.description.tc | 11 | - |
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