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Gastroprotective Action of Cochinchina Momordica Seed Extract Is Mediated by Activation of CGRP and Inhibition of cPLA(2)/5-LOX Pathway
DC Field | Value | Language |
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dc.contributor.author | Kang, Jung Mook | - |
dc.contributor.author | Kim, Nayoung | - |
dc.contributor.author | Kim, Bongcheol | - |
dc.contributor.author | Kim, Joo-Hyon | - |
dc.contributor.author | Park, Ji Hyun | - |
dc.contributor.author | Lee, Hye Seung | - |
dc.contributor.author | Kim, Joo Sung | - |
dc.contributor.author | Song, In Sung | - |
dc.contributor.author | Jung, Hyun Chae | - |
dc.contributor.author | Jang, In-Jin | - |
dc.contributor.author | Lee, Mi Kyoung | - |
dc.contributor.author | Lee, Bong-Yong | - |
dc.date.accessioned | 2012-05-23T04:28:34Z | - |
dc.date.available | 2012-05-23T04:28:34Z | - |
dc.date.issued | 2009-12 | - |
dc.identifier.citation | DIGESTIVE DISEASES AND SCIENCES; Vol.54 12; 2549-2560 | ko_KR |
dc.identifier.issn | 0163-2116 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76320 | - |
dc.description.abstract | Cochinchina momordica seed extract (SK-MS10), which is composed of the major compounds momordica saponins, has been evaluated for its gastroprotective effects in rat models of acute gastric mucosal damage. Ethanol and water immersion restraint stress (WRS) induced gastric damage, including hemorrhages and edema, was significantly attenuated by pretreatment with SK-MS10. In addition, SK-MS10 reduced increases of mucosal myeloperoxidase (MPO), IL-1 beta, and TNF alpha levels and the expression of cPLA(2), and 5-LOX induced by ethanol or WRS. SK-MS10 also increased hexosamine, adherent mucus, and the expression of MUC5AC. Furthermore, SK-MS10 enhanced the mucosal expression of the CGRP gene and its serum levels. N (G)-methyl L-arginine (L-NMMA) or capsaicin desensitization reversed the SK-MS10-induced gastroprotection effect. These results suggest that SK-MS10 is a gastroprotective agent against acute gastric mucosal damage by suppressing proinflammatory cytokines, down-regulating cPLA2, 5-LOX, and increasing the synthesis of mucus. Furthermore, CGRP-NO pathway was found to play an important role in these gastroprotective effects of SK-MS10. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | SPRINGER | ko_KR |
dc.subject | Cochinchina momordica | ko_KR |
dc.subject | Nitric oxide | ko_KR |
dc.subject | Calcitonin gene-related peptide | ko_KR |
dc.subject | Gastroprotection | ko_KR |
dc.title | Gastroprotective Action of Cochinchina Momordica Seed Extract Is Mediated by Activation of CGRP and Inhibition of cPLA(2)/5-LOX Pathway | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 강정묵 | - |
dc.contributor.AlternativeAuthor | 김나영 | - |
dc.contributor.AlternativeAuthor | 김봉철 | - |
dc.contributor.AlternativeAuthor | 김주현 | - |
dc.contributor.AlternativeAuthor | 이봉용 | - |
dc.contributor.AlternativeAuthor | 박지현 | - |
dc.contributor.AlternativeAuthor | 이미경 | - |
dc.contributor.AlternativeAuthor | 이혜승 | - |
dc.contributor.AlternativeAuthor | 장인진 | - |
dc.contributor.AlternativeAuthor | 김주성 | - |
dc.contributor.AlternativeAuthor | 정현채 | - |
dc.contributor.AlternativeAuthor | 송인성 | - |
dc.identifier.doi | 10.1007/s10620-008-0671-6 | - |
dc.citation.journaltitle | DIGESTIVE DISEASES AND SCIENCES | - |
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dc.description.tc | 2 | - |
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