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Regulatory Effect of Common Promoter Polymorphisms on the Expression of the 11 beta-Hydroxysteroid Dehydrogenase Type 1 Gene

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dc.contributor.authorKu, Yun Hyi-
dc.contributor.authorKoo, Bo Kyung-
dc.contributor.authorKwak, Soo Heon-
dc.contributor.authorCho, Young Min-
dc.contributor.authorLee, Hong Kyu-
dc.contributor.authorChoi, Jung-Won-
dc.contributor.authorPark, Kyong Soo-
dc.contributor.authorOh, Bermseok-
dc.contributor.authorKim, Yeonjung-
dc.contributor.authorShin, Hyoung Doo-
dc.date.accessioned2012-05-23T07:00:49Z-
dc.date.available2012-05-23T07:00:49Z-
dc.date.issued2009-
dc.identifier.citationHORMONE RESEARCH; Vol.72 1; 25-32ko_KR
dc.identifier.issn0301-0163-
dc.identifier.urihttp://hdl.handle.net/10371/76336-
dc.description.abstractBackground/Aims: Glucocorticoids play an important role in the pathogenesis of obesity and insulin resistance. 11 beta-hydroxysteroid dehydrogenase type 1 (HSD11B1), which converts inactive cortisone to active cortisol, has become an emerging therapeutic target for type 2 diabetes mellitus and obesity. In this study, we examined the association between HSD11B1 polymorphisms and type 2 diabetes and metabolic phenotypes in Koreans. Methods: We sequenced all exons including exon-intron boundaries and the promoter region of the HSD11B1 gene. Of 8 polymorphisms identified, we selected 4 common single-nucleotide polymorphisms (g.-19835G>A, g.-19609A>G, g.+27447G>C and g.+27810C>T) based on location, linkage disequilibrium and frequency and which were genotyped in 757 subjects with type 2 diabetes and 644 nondiabetic subjects. Results: There was no association between the 4 common polymorphisms of HSD11B1 and type 2 diabetes. g.-19835G>A and g.-19609A>G showed modest associations with fasting plasma glucose and body mass index but the significance of these associations was lost after adjustment for multiple comparison. With regard to promoter polymorphisms in the HSD11B1 gene, a haplotype construct carrying both g.-19835A and g.-19609G showed significantly decreased promoter activity compared to other common haplotype constructs. Conclusion: The variations in HSD11B1 were not associated with susceptibility to type 2 diabetes or metabolic phenotypes in Koreans. However, the common promoter variants of the gene might exert a polymorphic regulatory effect on HSD11B1 expression. Copyright (C) 2009 S. Karger AG, Baselko_KR
dc.description.sponsorshipThis work was supported by the Korea Health 21 R & D Project,
Korean Ministry of Health, Welfare and Family Affairs (Grant
No. 00-PJ3-PG6-GN07-001).
ko_KR
dc.language.isoenko_KR
dc.publisherKARGERko_KR
dc.subject11 beta-Hydroxysteroid dehydrogenase type 1ko_KR
dc.subjectObesityko_KR
dc.subjectDiabetes mellitus, type 2ko_KR
dc.subjectPolymorphismko_KR
dc.titleRegulatory Effect of Common Promoter Polymorphisms on the Expression of the 11 beta-Hydroxysteroid Dehydrogenase Type 1 Geneko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor구윤희-
dc.contributor.AlternativeAuthor구보경-
dc.contributor.AlternativeAuthor곽수현-
dc.contributor.AlternativeAuthor조영민-
dc.contributor.AlternativeAuthor신형두-
dc.contributor.AlternativeAuthor이홍규-
dc.contributor.AlternativeAuthor김연정-
dc.contributor.AlternativeAuthor최정원-
dc.contributor.AlternativeAuthor오범석-
dc.contributor.AlternativeAuthor박경수-
dc.identifier.doi10.1159/000224337-
dc.citation.journaltitleHORMONE RESEARCH-
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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