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Polymorphisms of ADIPOR1 and ADIPOR2 are associated with phenotypes of type 2 diabetes in Koreans
DC Field | Value | Language |
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dc.contributor.author | Kim, Jin Taek | - |
dc.contributor.author | Kim, Yeonjung | - |
dc.contributor.author | Cho, Young Min | - |
dc.contributor.author | Koo, Bo Kyung | - |
dc.contributor.author | Shin, Hyoung Doo | - |
dc.contributor.author | Choi, Jung Won | - |
dc.contributor.author | Park, Kyong Soo | - |
dc.contributor.author | Oh, Bermseok | - |
dc.contributor.author | Jang, Hak Chul | - |
dc.contributor.author | Lee, Eun Kyung | - |
dc.date.accessioned | 2012-05-23T07:08:22Z | - |
dc.date.available | 2012-05-23T07:08:22Z | - |
dc.date.issued | 2009-01 | - |
dc.identifier.citation | CLINICAL ENDOCRINOLOGY; Vol.70 1; 66-74 | ko_KR |
dc.identifier.issn | 0300-0664 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76338 | - |
dc.description.abstract | Adiponectin receptors 1 and 2 (ADIPOR1 and ADIPOR2) are considered as candidate genes for type 2 diabetes because they mediate the metabolic effects of adiponectin on target tissues. We investigated whether common polymorphisms of ADIPOR1 and ADIPOR2 are associated with type 2 diabetes or its related phenotypes in Koreans. By sequencing of the DNA samples from 24 unrelated Korean subjects, we selected seven single nucleotide polymorphisms (SNPs) from ADIPOR1 and four SNPs from ADIPOR2 for genotyping in 757 type 2 diabetic patients and 644 nondiabetic subjects. None of the SNPs were associated with the risk of type 2 diabetes. However, g.-7309A > G (rs75172865) in ADIPOR1 was associated with lower insulin resistance, measured by the homeostasis model assessment of insulin resistance (HOMA-IR). Thereafter, we transfected three different human cell lines with plasmids harbouring g.-7309A > G and found that this variant reduced the promoter activity of ADIPOR1. In ADIPOR2, g.-63442G (novel SNP) and g.33447T (rs1044471) were associated with smaller waist circumference. None of the SNPs in either ADIPOR1 or ADIPOR2 were associated with the risk of type 2 diabetes in Koreans. However, the altered activity of the ADIPOR1 promoter was associated with insulin resistance and SNPs of ADIPOR2 were associated with waist circumference. | ko_KR |
dc.description.sponsorship | This work was supported by the Korean Health 21 R&D Project,
Korean Ministry of Health and Welfare (grant no. 00-PJ3-PG6- GN07-001) and an intramural grant from the National Institute of Health, Korea. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | WILEY-BLACKWELL PUBLISHING, INC | ko_KR |
dc.title | Polymorphisms of ADIPOR1 and ADIPOR2 are associated with phenotypes of type 2 diabetes in Koreans | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김진택 | - |
dc.contributor.AlternativeAuthor | 김연정 | - |
dc.contributor.AlternativeAuthor | 조영민 | - |
dc.contributor.AlternativeAuthor | 구보경 | - |
dc.contributor.AlternativeAuthor | 이은경 | - |
dc.contributor.AlternativeAuthor | 신형두 | - |
dc.contributor.AlternativeAuthor | 장학철 | - |
dc.contributor.AlternativeAuthor | 최정원 | - |
dc.contributor.AlternativeAuthor | 오범석 | - |
dc.contributor.AlternativeAuthor | 박경수 | - |
dc.identifier.doi | 10.1111/j.1365-2265.2008.03296.x | - |
dc.citation.journaltitle | CLINICAL ENDOCRINOLOGY | - |
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dc.description.tc | 3 | - |
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