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Prevalence of Occult Hepatitis B Virus Infection in a General Adult Population in Korea
DC Field | Value | Language |
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dc.contributor.author | Song, Eun Young | - |
dc.contributor.author | Yun, Yeo Min | - |
dc.contributor.author | Park, Myoung Hee | - |
dc.contributor.author | Seo, Dong Hee | - |
dc.date.accessioned | 2012-05-24T05:56:25Z | - |
dc.date.available | 2012-05-24T05:56:25Z | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | INTERVIROLOGY; Vol.52 2; 57-62 | ko_KR |
dc.identifier.issn | 0300-5526 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76414 | - |
dc.description.abstract | Objectives: We investigated the prevalence of hepatitis B virus (HBV) markers and occult HBV infection in a general adult population in Korea. Methods: HBsAg, anti-HBs and antiHBc were analyzed on 1,091 samples of routine medical check-up examinees by chemiluminescence immunoassay. Nucleic acid amplification test (NAT) was performed on 1,047 HBsAg-negative samples by multiplex real-time polymerase chain reaction (PCR) kit for simultaneous detection of HBV, hepatitis C virus, and human immunodeficiency virus (Cobas Taqscreen MPX) in pools of six and reactive pools were resolved to individual samples, and further discriminated by PCR-based assay for HBV (Cobas Ampliscreen HBV). Results: The prevalences of HBsAg, anti-HBc, and anti-HBs were 4.0, 39.3, and 75.4%, respectively. The prevalence of anti-HBc significantly decreased with decreasing age (p < 0.001). Occult HBV infection was found in 7 (0.7%) of 1,047 HBsAg-negative subjects, and 5 of them were anti-HBc-negative. Sequencing of HBV S gene in 3 cases revealed one wild-type and two mutant strains (W74S, F85Y; T63I, W74S, T131N substitutions). Conclusions: This study helps to understand the current status of hepatitis B infection and the prevalence of occult HBV infection in a general adult population in Korea. Copyright (C) 2009 S. Karger AG, Basel | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | KARGER | ko_KR |
dc.subject | Prevalence | ko_KR |
dc.subject | Hepatitis B surface antigen | ko_KR |
dc.subject | Anti-HBs | ko_KR |
dc.subject | Hepatitis B virus DNA | ko_KR |
dc.subject | Occult hepatitis B virus infection | ko_KR |
dc.subject | Anti-HBc | ko_KR |
dc.title | Prevalence of Occult Hepatitis B Virus Infection in a General Adult Population in Korea | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 송은영 | - |
dc.contributor.AlternativeAuthor | 윤여민 | - |
dc.contributor.AlternativeAuthor | 박명희 | - |
dc.contributor.AlternativeAuthor | 서동희 | - |
dc.identifier.doi | 10.1159/000214633 | - |
dc.citation.journaltitle | INTERVIROLOGY | - |
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dc.description.tc | 11 | - |
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