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Genetic variation of IL13 as a risk factor of reduced lung function in children and adolescents: A cross-sectional population-based study in Korea
DC Field | Value | Language |
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dc.contributor.author | Park, Heung-Woo | - |
dc.contributor.author | Lee, Jong-Eun | - |
dc.contributor.author | Kim, Se-Hoon | - |
dc.contributor.author | Kim, Yoon-Keun | - |
dc.contributor.author | Kim, You-Young | - |
dc.contributor.author | Cho, Sang-Heon | - |
dc.contributor.author | Min, Kyung-Up | - |
dc.date.accessioned | 2012-05-25T01:41:09Z | - |
dc.date.available | 2012-05-25T01:41:09Z | - |
dc.date.issued | 2009-02 | - |
dc.identifier.citation | RESPIRATORY MEDICINE; Vol.103 2; 284-288 | ko_KR |
dc.identifier.issn | 0954-6111 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76449 | - |
dc.description.abstract | Background: Previous investigations have suggested that genetic variations are associated with reduced lung function in early childhood. This study was conducted to evaluate the association between IL13 + 2044G -> A, the functionally relevant single nucleotide polymorphism (SNP) in the gene coding IL13, and lung function in early childhood. Patients and methods: A total of 1900 subjects aged 10-18 years living in Korea, were randomly recruited. Lung function test and methacholine bronchial provocation test were performed. Multiple regression analysis adjusting for sex, age, height, atopy, and history of passive smoking was done to evaluate effect of IL13 + 2044G -> A on lung function. Results: Mean (SD) forced expiratory volume in 1s (FEV(1)) was 2.66 L (+/- 0.60) in subjects with the AA or AG genotype (n = 982) and 2.75 L (+/- 0.57) in subjects with the GG genotype In = 918). IL13 + 2044G -> A showed a significant association with FEV(1) [in the minor allele dominant model (GG vs. AG + AA), P < 0.001]. Interestingly, the association between FEV(1) and IL13 + 2044G -> A remained still significant in subgroup analysis according to the presence of AHR (P < 0.001 in subjects without AHR and P = 0.002 in subjects with AHR). Moreover, FEV(1)/FVC (forced vital. capacity) ratio also showed a significant association with IL13 + 2044G -> A in both groups (P < 0.001 in subjects without AHR and P < 0.001 in subjects with AHR). This cross-sectional study demonstrates that IL13 + 2044G -> A is significantly associated with a reduced lung function in Korean children and adolescents. (C) 2008 Elsevier Ltd. All rights reserved. | ko_KR |
dc.description.sponsorship | This work was supported by the Korea Health 21 R&D Project Grant 03-PJ10-PG13-GD01-0002 and the Clinical Research Center for
Chronic Obstructive Airway Disease Grant 0412-CR03-0704-0001from the Korean Ministry of Health and Welfare. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | Elsevier | ko_KR |
dc.subject | Lung function | ko_KR |
dc.subject | IL13 | ko_KR |
dc.subject | Polymorphism | ko_KR |
dc.subject | Children | ko_KR |
dc.title | Genetic variation of IL13 as a risk factor of reduced lung function in children and adolescents: A cross-sectional population-based study in Korea | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 박흥우 | - |
dc.contributor.AlternativeAuthor | 이종은 | - |
dc.contributor.AlternativeAuthor | 김세훈 | - |
dc.contributor.AlternativeAuthor | 김윤근 | - |
dc.contributor.AlternativeAuthor | 민경업 | - |
dc.contributor.AlternativeAuthor | 김유영 | - |
dc.contributor.AlternativeAuthor | 조상헌 | - |
dc.identifier.doi | 10.1016/j.rmed.2008.08.009 | - |
dc.citation.journaltitle | RESPIRATORY MEDICINE | - |
dc.description.citedreference | Sadeghnejad A, 2008, RESP RES, V9, DOI 10.1186/1465-9921-9-2 | - |
dc.description.citedreference | Leung TF, 2007, CLIN EXP ALLERGY, V37, P1480, DOI 10.1111/j.1365-2222.2007.02799.x | - |
dc.description.citedreference | Stern DA, 2007, LANCET, V370, P758 | - |
dc.description.citedreference | Kim JJ, 2007, EUR ARCH OTO-RHINO-L, V264, P395, DOI 10.1007/s00405-006-0204-x | - |
dc.description.citedreference | Park HW, 2006, J ALLERGY CLIN IMMUN, V117, P774, DOI 10.1016/j.jaci.2005.12.1328 | - |
dc.description.citedreference | Ober C, 2006, GENES IMMUN, V7, P95, DOI 10.1038/sj.gene.6364284 | - |
dc.description.citedreference | Kim HB, 2006, J HUM GENET, V51, P1055, DOI 10.1007/s10038-006-0061-x | - |
dc.description.citedreference | Simpson A, 2005, AM J RESP CRIT CARE, V172, P55, DOI 10.1164/rccm.200412-1708OC | - |
dc.description.citedreference | Vladich FD, 2005, J CLIN INVEST, V115, P747, DOI 10.1172/JCI200522818 | - |
dc.description.citedreference | Hegab AE, 2004, CHEST, V126, P1832 | - |
dc.description.citedreference | Chen WG, 2004, J ALLERGY CLIN IMMUN, V114, P553, DOI 10.1016/j.jaci.2004.04.044 | - |
dc.description.citedreference | Khoo SK, 2004, J ALLERGY CLIN IMMUN, V113, P475, DOI 10.1016/j.jaci.2003.10.043 | - |
dc.description.citedreference | Han W, 2004, CLIN CANCER RES, V10, P124 | - |
dc.description.citedreference | Jakubzick C, 2004, IMMUNOL RES, V30, P339 | - |
dc.description.citedreference | Elias JA, 2003, CHEST, V123, p339S | - |
dc.description.citedreference | He JQ, 2003, AM J RESP CELL MOL, V28, P379, DOI 10.1165/rcmb.4885 | - |
dc.description.citedreference | Kraan TCTMV, 2002, GENES IMMUN, V3, P436 | - |
dc.description.citedreference | Belperio JA, 2002, AM J RESP CELL MOL, V27, P419, DOI 10.1165/rcmb.2002-00089OC | - |
dc.description.citedreference | Kim YK, 2002, CLIN EXP ALLERGY, V32, P1305, DOI 10.1046/j.1365-2745.2002.01478.x | - |
dc.description.citedreference | Kumar RK, 2002, CLIN EXP ALLERGY, V32, P1104 | - |
dc.description.citedreference | Rasmussen F, 2002, AM J RESP CRIT CARE, V165, P1480, DOI 10.1164/rccm.2108009 | - |
dc.description.citedreference | Zhu Z, 2001, AM J RESP CRIT CARE, V164, pS67 | - |
dc.description.citedreference | Grol MH, 1999, AM J RESP CRIT CARE, V160, P1830 | - |
dc.description.citedreference | ULICK CS, 1999, AM J RESP CRIT CARE, V160, P40 | - |
dc.description.citedreference | 1993, EUR RESP J, V16, P1 | - |
dc.description.citedreference | SHERRILL D, 1992, PEDIATR PULM, V13, P78 | - |
dc.description.citedreference | PEAT JK, 1991, AM REV RESPIR DIS, V144, P663 | - |
dc.description.citedreference | REDLINE S, 1989, AM REV RESPIR DIS, V140, P179 | - |
dc.description.tc | 3 | - |
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